Chapter 18, Problem 22P

Interpretation Introduction

Interpretation: For each, the synthesis starting from diethyl malonate and any other required reagent is to be outlined.

Concept introduction:

The synthesis of mono di-substituted acetic acid that is a useful counterpart of acetoacetic ester synthesis is called malonic ester synthesis.

In malonic ester synthesis, the starting material is malonic ester and the most commonly used malonic ester is diethyl malonate.