Chapter 18, Problem 18.38P

Interpretation Introduction

(a)

Interpretation:

Whether the given pair of reactants are suitable for a Robinson annulation is to be determined. If they are suitable, a detailed mechanism of the Robinson annulation that will occur is to be drawn.

Concept introduction:

A Robinson annulation reaction is a Michael reaction, the conjugate addition of an enolate anion followed by intramolecular aldol condensation. One of the reactants of Robinson annulation must be an $\text{α, β-}$ unsaturated carbonyl compound with two acidic $\text{α}$-protons. The second must be a ketone or aldehyde with one acidic $\text{α}$-proton.

Interpretation Introduction

(b)

Interpretation:

Whether the given pair of reactants are suitable for a Robinson annulation is to be determined. If they are suitable, a detailed mechanism of the Robinson annulation that will occur is to be drawn.

Concept introduction:

A Robinson annulation reaction is the conjugate addition of an enolate anion followed by intramolecular aldol condensation. One of the reactants of Robinson annulation must be an $\text{α, β-}$ unsaturated carbonyl compound with two acidic $\text{α}$-protons. The second must be a ketone or aldehyde with one acidic $\text{α}$-proton.

Interpretation Introduction

(c)

Interpretation:

Whether the given pair of reactants are suitable for a Robinson annulation is to be determined. If they are suitable, a detailed mechanism of the Robbinson annulation that will occur is to be drawn.

Concept introduction:

A Robinson annulation reaction is the conjugate addition of an enolate anion followed by intramolecular aldol condensation. One of the reactants of Robinson annulation must be an $\text{α}$, $\text{β}$-unsaturated carbonyl compound with two acidic $\text{α}$-hydrogens. The second must be a ketone or aldehyde with one acidic $\text{α}$-hydrogen.

Interpretation Introduction

(d)

Interpretation:

Whether the given pair of reactants are suitable for Robinson annulation is to be determined. If they are suitable, a detailed mechanism of the Robbinson annulation that will occur is to be drawn.

Concept introduction:

Robinson annulation reaction is the conjugate addition of an enolate anion followed by intramolecular aldol condensation. One of the reactants of a Robinson annulation must be an $\text{α, β-}$ unsaturated carbonyl compound with two acidic $\text{α}$-protons. The second must be a ketone or aldehyde with one acidic $\text{α}$-proton.