Genetics: Analysis and Principles
6th Edition
ISBN: 9781259616020
Author: Robert J. Brooker Professor Dr.
Publisher: McGraw-Hill Education
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Chapter 15, Problem 7CONQ
Summary Introduction
To review:
The mechanismsused by steroid receptors and CREB protein (cyclic adenosine phosphate response element-binding protein) to regulate the activity of transcription factors.
Introduction:
The three main mechanisms for the action of transcription factors are covalent modification, interactions between proteins, and binding of a small effector molecule. The binding of atranscription factor to the DNA(Deoxyribonucleic Acid) and transcription by RNA (ribonucleic acid) polymerase can be determined by these modulating effects.
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Which of the following is the most likely result of a mutation in the lac operator that prevents release of the depressor protein?
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Chapter 15 Solutions
Genetics: Analysis and Principles
Ch. 15.1 - 1. Combinatorial control refers to the phenomenon...Ch. 15.1 - 2. A regulatory transcription factor protein...Ch. 15.1 - 3. A bidirectional enhancer has the following...Ch. 15.1 - 4. Regulatory transcription factors can be...Ch. 15.2 - 1. A chromatin-remodeling complex may
a. change...Ch. 15.2 - Prob. 2COMQCh. 15.2 - 3. Which of the following characteristics is...Ch. 15.2 - 4. Transcriptional activation of eukaryotic genes...Ch. 15.3 - How can methylation affect transcription? a. It...Ch. 15.3 - 2. The process in which completely unmethylated...
Ch. 15.4 - Prob. 1COMQCh. 15.5 - The overall goal of the ENCODE Project is a. to...Ch. 15.6 - The binding of iron regulatory protein (IRP) to...Ch. 15 - Discuss the common points of control in eukaryotic...Ch. 15 - 2. Discuss the structure and function of...Ch. 15 - 3. What is meant by the term transcription factor...Ch. 15 - What are the functions of transcriptional...Ch. 15 - 5. Is each of the following statements true or...Ch. 15 - 6. Transcription factors usually contain one or...Ch. 15 - Prob. 7CONQCh. 15 - Prob. 8CONQCh. 15 - 9. Let’s suppose a mutation in the glucocorticoid...Ch. 15 - Prob. 10CONQCh. 15 - Prob. 11CONQCh. 15 - Prob. 12CONQCh. 15 - 13. Transcription factors such as the...Ch. 15 - An enhancer, located upstream from a gene, has the...Ch. 15 - 15. The DNA-binding domain of each CREB protein...Ch. 15 - The gene that encodes the enzyme called tyrosine...Ch. 15 - Prob. 17CONQCh. 15 - 18. What is a histone variant?
Ch. 15 - Prob. 19CONQCh. 15 - 20. What is meant by the term histone code? With...Ch. 15 - Prob. 21CONQCh. 15 - Histones are thought to be displaced as RNA...Ch. 15 - 23. What is an insulator? Describe two different...Ch. 15 - 24. What is DNA methylation? When we say that DNA...Ch. 15 - Lets suppose that a vertebrate organism carries a...Ch. 15 - 26. What is a CpG island? Where would you expect...Ch. 15 - Describe how the binding of iron regulatory...Ch. 15 - 1. Briefly describe the method of chromatin...Ch. 15 - Researchers can isolate a sample of cells, such as...Ch. 15 - Prob. 3EQCh. 15 - Prob. 4EQCh. 15 - Prob. 5EQCh. 15 - 6. As described in Chapter 21, an electrophoretic...Ch. 15 - Prob. 7EQCh. 15 - 1. Explain how DNA methylation could be used to...Ch. 15 - 2. Enhancers can occur almost anywhere in DNA and...
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- Briefly name and explain five mechanisms by which transcription factors activate transcription, with specific reference to targets in the basal transcription complexarrow_forwardPlease arrangearrow_forwardWhat is meant by the term transcription factor modulation? List three general ways this can occur.arrow_forward
- Explain Molecular Mechanisms of Transcription Repression and Activation.arrow_forwardDescribe briefly the generation of the active form of the transcription factor NFAT. Include the following terms: Lck. Zap 70, P IP2, IP3, calmodulin, calcineurin (and other relevant ones).arrow_forwardUsing CREB and nuclear receptors as examples,compare and contrast the structural changes that takeplace when these transcription factors bind to their coactivatorsarrow_forward
- How does the activity of human p53 get regulated through the interaction of the transactivation domains with its corresponding macromolecules when the cell is under stress vs unstressed conditions? based on this articles Primary paper: Lee, C. W., Martinez-Yamout, M. A., Dyson, H. J., & Wright, P. E. (2010). Structure of the p53 Transactivation Domain in Complex with the Nuclear Receptor Coactivator Binding Domain of CREB Binding Protein. Biochemistry, 49(46), 9964–9971. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2982890/#SD1 https://www.rcsb.org/structure/2L14 PDB file for TAD domainarrow_forwardDefine the Mechanisms of Transcription Repression ?arrow_forwardDescribe the basic models of transcription factor families, the two transcription factors each representing these models, and how they function molecularly by specifying some of their functions.arrow_forward
- Explain how the expression of a single gene can be quickly,efficiently,and specifically shut down at the transcriptional,posttranscriptional,and posttranslational stages through thecoordinated expression of a transcriptional repressor, an miRNA,and a ubiquitin ligase.arrow_forwardDescribe three ways that the function of a regulatory transcription factor can be modulated.arrow_forwardHow are the actions of lac repressor and trp repressor similar and how are they different with regard to their binding to operator sites, their effects on transcription, and the influences of small effector molecules?arrow_forward
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