Study Guide for Campbell Biology
11th Edition
ISBN: 9780134443775
Author: Lisa A. Urry, Michael L. Cain, Steven A. Wasserman, Peter V. Minorsky, Jane B. Reece, Martha R. Taylor, Michael A. Pollock
Publisher: PEARSON
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Chapter 15, Problem 4SYK
Summary Introduction
To explain: The adverse phenotypic effects associated with chromosomal alterations.
Introduction: The male fruit flies have one X chromosome and one Y chromosome, and the female fruit flies have a pair of homologous X chromosomes. The normal
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Achondroplasia is an autosomal dominant disorder characterized by disproportionate short stature: the legs and arms of people with achondroplasia are short compared with the head and trunk. The disorder is due to a base substitution in the gene, located on the short arm of chromosome 4, that encodes fibroblast growth factor receptor 3 (FGFR3). Although achondroplasia is clearly inherited as an autosomal dominant trait, more than 80% of the people who have achondroplasia are born to parents with normal stature. This high percentage indicates that most cases are caused by newly arising mutations; these cases (not inherited from an affected parent) are referred to as sporadic. Studies have demonstrated that sporadic cases of achondroplasia are almost always caused by mutations inherited from the father (paternal mutations). In addition, the occurrence of achondroplasia is higher among the children of older fathers; approximately 50% of children with achondroplasia are born to fathers…
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Faulty Tooth Enamel Formation Amelogenesis imperfecta (AI) is a disorder of faulty tooth enamel formation. It is inherited in an autosomal dominant and X-linked dominant pattern. The expression of AI disorder is determined by mutations in the autosomal alleles. One copy of the mutated allele (A) will cause the disorder. The severity of the disorder is determined by mutations in a gene carried on the X chromosome. Normal (or non-severe) abnormality (XN) is dominant over the abnormality (or severe) (Xn) allele. In the absence of the autosomal dominant allele, the abnormality gene on the X chromosome is notexpressed. Question:A woman with normal teeth had four children with a man with non-severe form of AI:
A boy was born without amelogenesis imperfecta
A girl was born without amelogenesis imperfecta
A boy was born with severe amelogenesis imperfecta
A boy was born with non severe amelogenesis imperfecta
Identify the parental genotypes.
Complete the Punnett square for the parental…
Chapter 15 Solutions
Study Guide for Campbell Biology
Ch. 15 - Complete the following summary of Morgans crosses...Ch. 15 - Two normal color-sighted individuals have two...Ch. 15 - In a testcross between a heterozygote tall,...Ch. 15 - With unlinked genes, an equal number of parental...Ch. 15 - The following recombination frequencies have been...Ch. 15 - a. What is the difference between an organism with...Ch. 15 - Prob. 7IQCh. 15 - Prob. 8IQCh. 15 - Mendels law of independent assortment applies to...Ch. 15 - You have found a new mutant phenotype in fruit...
Ch. 15 - Prob. 3SYKCh. 15 - Prob. 4SYKCh. 15 - Thomas Hunt Morgan firmly established the location...Ch. 15 - Prob. 2TYKCh. 15 - Sex-linked traits a. are coded for by genes...Ch. 15 - Prob. 4TYKCh. 15 - Prob. 5TYKCh. 15 - Prob. 6TYKCh. 15 - Prob. 7TYKCh. 15 - Prob. 8TYKCh. 15 - Prob. 9TYKCh. 15 - Prob. 10TYKCh. 15 - Consider three genes on the X chromosome: A, B,...Ch. 15 - Prob. 12TYKCh. 15 - Genomic imprinting a. explains cases in which the...Ch. 15 - Prob. 14TYKCh. 15 - Prob. 15TYKCh. 15 - Suppose that alleles for an X-linked character for...Ch. 15 - Some girls who fail to undergo puberty are found...Ch. 15 - Prob. 18TYKCh. 15 - The genetic event that results in Turner syndrome...Ch. 15 - Prob. 20TYKCh. 15 - Prob. 1GPCh. 15 - Prob. 2GPCh. 15 - Prob. 3GPCh. 15 - Prob. 4GPCh. 15 - Prob. 5GPCh. 15 - Red-green color blindness is caused by a...
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- What chromosomal abnormality can result from dispermy?arrow_forwardPresent clinical consequences of most commonly identified numerical chromosome abnormalities.arrow_forwardAmelogenesis imperfecta (AI) is a disorder of faulty tooth enamel formation. It is inherited in an autosomal dominant and X-linked dominant pattern. The expression of AI disorder is determined by mutations in the autosomal alleles. One copy of the mutated allele (A) will cause the disorder. The severity of the disorder is determined by mutations in a gene carried on the X chromosome. Normal (or non-severe) abnormality (XN) is dominant over the abnormality (or severe) (Xn) allele. In the absence of the autosomal dominant allele, the abnormality gene on the X chromosome is not expressed. Question:A woman with normal teeth had four children with a man with non-severe form of AI: A boy was born without amelogenesis imperfecta A girl was born without amelogenesis imperfecta A boy was born with severe amelogenesis imperfecta A boy was born with non severe amelogenesis imperfecta Identify the parental genotypes. Complete the Punnett square for the parental cross, and identify the…arrow_forward
- Amelogenesis imperfecta (AI) is a disorder of faulty tooth enamel formation. It is inherited in an autosomal dominant and X-linked dominant pattern. The expression of AI disorder is determined by mutations in the autosomal alleles. One copy of the mutated allele (A) will cause the disorder. The severity of the disorder is determined by mutations in a gene carried on the X chromosome. Normal (or non-severe) abnormality (XN) is dominant over the abnormality (or severe) (Xn) allele. In the absence of the autosomal dominant allele, the abnormality gene on the X chromosome is notexpressed. Question:A woman with normal teeth had four children with a man with non-severe form of AI: A boy was born without amelogenesis imperfecta A girl was born without amelogenesis imperfecta A boy was born with severe amelogenesis imperfecta A boy was born with non severe amelogenesis imperfecta Identify the parental genotypes. Complete the Punnett square for the parental cross, and identify the possible…arrow_forwardAmelogenesis imperfecta (AI) is a disorder of faulty tooth enamel formation. It is inherited in an autosomal dominant and X-linked dominant pattern. The expression of AI disorder is determined by mutations in the autosomal alleles. One copy of the mutated allele (A) will cause the disorder. The severity of the disorder is determined by mutations in a gene carried on the X chromosome. Normal (or non-severe) abnormality (XN) is dominant over the abnormality (or severe) (Xn) allele. In the absence of the autosomal dominant allele, the abnormality gene on the X chromosome is not expressed. Question:A woman with normal teeth had four children with a man with non-severe form of AI: A boy was born without amelogenesis imperfecta A girl was born without amelogenesis imperfecta A boy was born with severe amelogenesis imperfecta A boy was born with non severe amelogenesis imperfecta Identify the parental genotypes. Complete the Punnett square for the parental cross, and identify the…arrow_forwardWhat causes most of the phenotypic abnormalities in someone with Down's Syndrome? A) They have many gene mutations that produce nonfunctional proteins. B) They express too much of some proteins during development. C) Their cells cannot go through mitosis properly during development because they have an odd number of chromosomes. D) Their chromosomes cannot pair during meiosis.arrow_forward
- Is Miller Fisher syndrome hereditary?arrow_forwardPancreatic cancer is clearly inherited as an autosomal dominant trait in the family illustrated in Figure 23.1. Yet most cases of pancreatic cancer are sporadic, appearing as isolated cases in families with no obvious inheritance. How can a trait be strongly inherited in one family and not inherited in another?arrow_forwardAnalyze the karyotype shown. Indicate if it is a chromosomal male or achromosomal female. If the karyotype is normal, write the word normal under name or description. If the karyotype is abnormal, name or describethe disorder.arrow_forward
- A patient has two parents with Huntington's disease. They may not have inherited this autosomal dominant disorder due to: 1) increased DNA repeats (CAG) during spermatogenesis O2) incomplete penetrance 3) inheriting one recessive allelearrow_forwardCampomelic dysplasia (CMD1) is a congenital humansyndrome featuring malformation of bone and cartilage.It is caused by an autosomal dominant mutation of agene located on chromosome 17. Consider the followingobservations in sequence, and in each case, draw whateverappropriate conclusions are warranted.(a) Of those with the syndrome who are karyotypically46,XY, approximately 75 percent are sex reversed,exhibiting a wide range of female characteristics.(b) The nonmutant form of the gene, called SOX9, isexpressed in the developing gonad of the XY male,but not the XX female.(c) The SOX9 gene shares 71 percent amino acid codingsequence homology with the Y-linked SRY gene.(d) CMD1 patients who exhibit a 46,XX karyotypedevelop as females, with no gonadal abnormalities.arrow_forwardTuberous Sclerosis (TS) is an autosomal dominant genetic disease characterized by seizures, mental retardation, autism, and benign tumors of the brain, heart, skin, and kidneys. The kidney tumors can also be malignant. This disease exhibits a wide range of severity, and only about 1/3 of the cases are inherited. Two different genes have been tightly linked to the disease in families where it is inherited. The remaining 2/3 appear to be due to mutations in one of the 2 genes as well. Overall it appears that 1/2 are caused by mutations in TSC1 and the other half by mutations in TSC2. A rat model for hereditary renal carcinoma (kidney cancer) has been found. Southern and Northern blot analysis of the TSC1 and TSC2 gene revealed no differences between these rats and normal rats. Not all the rats in the strain would get cancer but a significant proportion did and those were selected for and used in experiments. 1. a) What was detected by the Southern blots? (look this up, make your…arrow_forward
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