Concept explainers
(a)
Interpretation:
The chiral center of the clopidogrel needs to be labeled.
Concept introduction:
The molecules with a chiral center can form a superimposable mirror image and are known as enantiomers. There should not be any plane of symmetry in a molecule to be chiral. A plane that bisects a molecule into two equal halves is known as a plane of symmetry. If there is a plane of symmetry in a molecule and it is identical to any of its mirror image, it is considered as achiral. The chiral center is carbon attached to 4 different groups attached to it.
(b)
Interpretation:
The enantiomers of clopidogrel needs to be drawn.
Concept introduction:
The chiral molecules which are mirror images of each other are known as enantiomers. They are non-superimposable mirror images, or they cannot be placed on top of each other.
(c)
Interpretation:
The Fischer projections forClopidogrel needs to be drawn.
Concept introduction:
For a molecule with a chiral center, the Fischer projection formula is written to describe the stereo arrangement of atoms in two dimensions. For large molecules with more than 1 stereocenters are also represent their stereochemistry using the Fischer Projection. The carbon chain of the molecule containing the chiral carbon center is represented as a vertical line with chiral carbon at the center. Two other groups are then horizontally arranged around the chiral carbon atom.
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General, Organic, & Biological Chemistry
- 6. Each of the following pairs of compounds contains one chirality center. Determine whether they are the same compound or enantiomers. If they are superimposable, they are the same. If they are nonsuperimposable, they are mirror images, they are enantiomers. Br C1 I_CC1 I— H Ме- Me-C Br Et H Br Cl H C-I Me-C Et Br H I-C Br Me BrC-I H H Et-C Br Me Me H H-C Br Me Et 1 2 Sk 954~ Rost 45 r Siarrow_forwardTranslate the ball-and-stick model to a shorthand structure, and label the two chirality centers in vitamin K. Vitamin K is essential to blood clot formation. A defi ciency of this vitamin may lead to excessive and often fatal bleeding.arrow_forwardSimvastatin (trade name: Zocor™M) is a pharmaceutical used to treat elevated blood lipids (i.e. high cholesterol). It contains 7 chirality centers (which allows for 128 different stereoisomers!) Determine the configuration of each chirality center. HOL. O CH3 H O H Ou yot H O XII H по / CH3arrow_forward
- 1) The following compound, whose central ring is referred to as a 1,2,4-trioxane, is an anticancer agent that demonstrates activity against canine osteosarcoma. Assign the configuration of each chiral center and then draw all possible stereoisomers of this compound, showing the specific stereochemical relationship between each of your drawings. H -OH O-N O-Oarrow_forwardAssign R or S configuration to each chirality center in the following molecules. First assign the configuration of the chirality center closest to the top of the Fischer projection. Then give the configuration of the other chirality center. CH₂OH -OH CH3CH₂ # H- -OCH3 CO₂H 1st structure: Top chirality center 2nd structure: Top chirality center H3C- H3C- OH -OH -H Other chirality center: ✓. Other chirality center: Varrow_forwardIs the following compound chiral, and does it have an enantiomer? Me -Me It is chiral, and it has an enantiomer. It is chiral, but it does not have an enantiomer. It is not chiral, and it does not have an enantiomer. It is not chiral, but it does have an enantiomer.arrow_forward
- Organic Chemistry: A Guided InquiryChemistryISBN:9780618974122Author:Andrei StraumanisPublisher:Cengage Learning