ANATOMY & PHYSIOLOGY LL W/CONNECT ACCESS
ANATOMY & PHYSIOLOGY LL W/CONNECT ACCESS
4th Edition
ISBN: 9781265521363
Author: McKinley
Publisher: MCG
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Chapter 12.10, Problem 30WDYL
Summary Introduction

To determine:

How acetylcholine generates either EPSP or an IPSP.

Concept introduction:

A neurotransmitter is chemical substances which are released by the axon terminals at the time of arrival of the nerve impulses. These neurotransmitters are stored in synaptic vesicles. These vesicles then fuse with the sending membrane which results in the release of neurotransmitter into the synaptic cleft.

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Let’s say the synapses of a neuron’s dendrites are filled with glutamate-gated channels which, when activated by glutamate, cause an excitatory postsynaptic potential (EPSP) in the neuron. In one instance, glutamate is released at all of the synapses simultaneously and this leads to an action potential in the neuron. A) What type of summation of PSPs is this? Why? B) List the sequence of steps that occur starting from binding of glutamate to the glutamate-gated channels at the synapses and ending with the membrane potential at the axon hillock returning to resting potential at the end of the action potential. (Include all the changes in voltage-gated channels underlying the action potential.)

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