(a) Interpretation: The reason for the measurement of aggrecan degradation by the release of glycosaminoglycan needs to be explained. Concept introduction: The carbohydrates are combined with the proteins. Enzyme behaves aggrecan and produces a molecule.Some destruction can observe by the aggrecan.

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Answer 1

Question

Chapter 11, Problem 38P

Interpretation Introduction

(a)

Interpretation:

The reason for the measurement of aggrecan degradation by the release of glycosaminoglycan needs to be explained.

Concept introduction:

The carbohydrates are combined with the proteins. Enzyme behaves aggrecan and produces a molecule.Some destruction can observe by the aggrecan.

Interpretation Introduction

(b)

Interpretation:

The reason for the glycosaminoglycan release to not indicate the aggrecan degradation needs to be explained.

Concept introduction:

Glycosaminoglycan is also known as mucopolysaccharides which have a series of disaccharides. This series contains amino sugar and uronic sugar. Glycosaminoglycan is also written as GAGs.

Interpretation Introduction

(c)

Interpretation:

The purpose of the control needs to be explained.

Concept introduction:

Enzyme behaves aggrecan and producesa molecule. Some destruction can observe by the aggrecan.

Interpretation Introduction

(d)

Interpretation:

The effect of adding IL-2 needs to be explained.

Concept introduction:

IL-2 is also known as interleukin which is a signaling molecule of the immune system.

Interpretation Introduction

(e)

Interpretation:

The response of aggrecanase inhibitor when IL-2 is added needs to be explained.

Concept introduction:

IL-2 is also known as interleukin which is a signaling molecule of the immune system.

Interpretation Introduction

(f)

Interpretation:

The reason for aggrecan destruction in the control needs to be explained.

Concept introduction:

Enzyme behaves aggrecan and produces a molecule. Some destruction can observe by the aggrecan.

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Students have asked these similar questions

The beta-lactamase hydrolyzes the lactam-ring in penicillin. Describe the mechanism of hydrolysis, insuring to include the involvement of S, D, & K in the reaction sequence. Please help

To map the active site of beta-lactamase, the enzyme was hydrolyzed with trypsin to yield a hexapeptide (P1) with the following amino acids. Glu, Lys, Leu, Phe, Met, and Ser. Treatment of P1 with phenyl isothiocyanate yielded a PTH derivative of phenylalanine and a peptide (P2). Treatment of P1 with cyanogenbromide gave an acidic tetrapeptide (P3) and a dipeptide (P4).Treatment of P2 with 1-fluoro-2,4-dinitrobenzene, followed by complete hydrolysis, yields N-2,4-dinitrophenyl-Glu. P1, P2, and P3 contain the active site serine. Why doesn't D in this hexapeptide not participate in the hydrolysis of the beta-lactam ring even though S, K, and D are involved in the catalyst?

To map the active site of -lactamase, the enzyme was hydrolyzed with trypsin to yield a hexapeptide (P1) with the following amino acids. Glu, Lys, Leu, Phe, Met, and Ser. Treatment of P1 with phenyl isothiocyanate yielded a PTH derivative of phenylalanine and a peptide (P2). Treatment of P1 with cyanogenbromide gave an acidic tetrapeptide (P3) and a dipeptide (P4).Treatment of P2 with 1-fluoro-2,4-dinitrobenzene, followed by complete hydrolysis, yields N-2,4-dinitrophenyl-Glu. P1, P2, and P3 contain the active site serine. Using the experimental results described above derive the primary sequence of the active site hexapeptide. Please help!

Answer 2

Question

Chapter 11, Problem 38P

Interpretation Introduction

(a)

Interpretation:

The reason for the measurement of aggrecan degradation by the release of glycosaminoglycan needs to be explained.

Concept introduction:

The carbohydrates are combined with the proteins. Enzyme behaves aggrecan and produces a molecule.Some destruction can observe by the aggrecan.

Interpretation Introduction

(b)

Interpretation:

The reason for the glycosaminoglycan release to not indicate the aggrecan degradation needs to be explained.

Concept introduction:

Glycosaminoglycan is also known as mucopolysaccharides which have a series of disaccharides. This series contains amino sugar and uronic sugar. Glycosaminoglycan is also written as GAGs.

Interpretation Introduction

(c)

Interpretation:

The purpose of the control needs to be explained.

Concept introduction:

Enzyme behaves aggrecan and producesa molecule. Some destruction can observe by the aggrecan.

Interpretation Introduction

(d)

Interpretation:

The effect of adding IL-2 needs to be explained.

Concept introduction:

IL-2 is also known as interleukin which is a signaling molecule of the immune system.

Interpretation Introduction

(e)

Interpretation:

The response of aggrecanase inhibitor when IL-2 is added needs to be explained.

Concept introduction:

IL-2 is also known as interleukin which is a signaling molecule of the immune system.

Interpretation Introduction

(f)

Interpretation:

The reason for aggrecan destruction in the control needs to be explained.

Concept introduction:

Enzyme behaves aggrecan and produces a molecule. Some destruction can observe by the aggrecan.

Expert Solution & Answer

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See solution

Answer 3

Question

Chapter 11, Problem 38P

Interpretation Introduction

(a)

Interpretation:

The reason for the measurement of aggrecan degradation by the release of glycosaminoglycan needs to be explained.

Concept introduction:

The carbohydrates are combined with the proteins. Enzyme behaves aggrecan and produces a molecule.Some destruction can observe by the aggrecan.

Interpretation Introduction

(b)

Interpretation:

The reason for the glycosaminoglycan release to not indicate the aggrecan degradation needs to be explained.

Concept introduction:

Glycosaminoglycan is also known as mucopolysaccharides which have a series of disaccharides. This series contains amino sugar and uronic sugar. Glycosaminoglycan is also written as GAGs.

Interpretation Introduction

(c)

Interpretation:

The purpose of the control needs to be explained.

Concept introduction:

Enzyme behaves aggrecan and producesa molecule. Some destruction can observe by the aggrecan.

Interpretation Introduction

(d)

Interpretation:

The effect of adding IL-2 needs to be explained.

Concept introduction:

IL-2 is also known as interleukin which is a signaling molecule of the immune system.

Interpretation Introduction

(e)

Interpretation:

The response of aggrecanase inhibitor when IL-2 is added needs to be explained.

Concept introduction:

IL-2 is also known as interleukin which is a signaling molecule of the immune system.

Interpretation Introduction

(f)

Interpretation:

The reason for aggrecan destruction in the control needs to be explained.

Concept introduction:

Enzyme behaves aggrecan and produces a molecule. Some destruction can observe by the aggrecan.

Expert Solution & Answer

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Check out a sample textbook solution

See solution

Answer 4

Question

Chapter 11, Problem 38P

Interpretation Introduction

(a)

Interpretation:

The reason for the measurement of aggrecan degradation by the release of glycosaminoglycan needs to be explained.

Concept introduction:

The carbohydrates are combined with the proteins. Enzyme behaves aggrecan and produces a molecule.Some destruction can observe by the aggrecan.

Interpretation Introduction

(b)

Interpretation:

The reason for the glycosaminoglycan release to not indicate the aggrecan degradation needs to be explained.

Concept introduction:

Glycosaminoglycan is also known as mucopolysaccharides which have a series of disaccharides. This series contains amino sugar and uronic sugar. Glycosaminoglycan is also written as GAGs.

Interpretation Introduction

(c)

Interpretation:

The purpose of the control needs to be explained.

Concept introduction:

Enzyme behaves aggrecan and producesa molecule. Some destruction can observe by the aggrecan.

Interpretation Introduction

(d)

Interpretation:

The effect of adding IL-2 needs to be explained.

Concept introduction:

IL-2 is also known as interleukin which is a signaling molecule of the immune system.

Interpretation Introduction

(e)

Interpretation:

The response of aggrecanase inhibitor when IL-2 is added needs to be explained.

Concept introduction:

IL-2 is also known as interleukin which is a signaling molecule of the immune system.

Interpretation Introduction

(f)

Interpretation:

The reason for aggrecan destruction in the control needs to be explained.

Concept introduction:

Enzyme behaves aggrecan and produces a molecule. Some destruction can observe by the aggrecan.

Expert Solution & Answer

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See solution

Answer 5

Chapter 11, Problem 38P

Interpretation Introduction

(a)

Interpretation:

The reason for the measurement of aggrecan degradation by the release of glycosaminoglycan needs to be explained.

Concept introduction:

The carbohydrates are combined with the proteins. Enzyme behaves aggrecan and produces a molecule.Some destruction can observe by the aggrecan.

Interpretation Introduction

(b)

Interpretation:

The reason for the glycosaminoglycan release to not indicate the aggrecan degradation needs to be explained.

Concept introduction:

Glycosaminoglycan is also known as mucopolysaccharides which have a series of disaccharides. This series contains amino sugar and uronic sugar. Glycosaminoglycan is also written as GAGs.

Interpretation Introduction

(c)

Interpretation:

The purpose of the control needs to be explained.

Concept introduction:

Enzyme behaves aggrecan and producesa molecule. Some destruction can observe by the aggrecan.

Interpretation Introduction

(d)

Interpretation:

The effect of adding IL-2 needs to be explained.

Concept introduction:

IL-2 is also known as interleukin which is a signaling molecule of the immune system.

Interpretation Introduction

(e)

Interpretation:

The response of aggrecanase inhibitor when IL-2 is added needs to be explained.

Concept introduction:

IL-2 is also known as interleukin which is a signaling molecule of the immune system.

Interpretation Introduction

(f)

Interpretation:

The reason for aggrecan destruction in the control needs to be explained.

Concept introduction:

Enzyme behaves aggrecan and produces a molecule. Some destruction can observe by the aggrecan.

Answer 6

Chapter 11, Problem 38P

Interpretation Introduction

(a)

Interpretation:

The reason for the measurement of aggrecan degradation by the release of glycosaminoglycan needs to be explained.

Concept introduction:

The carbohydrates are combined with the proteins. Enzyme behaves aggrecan and produces a molecule.Some destruction can observe by the aggrecan.

Answer 7

Chapter 11, Problem 38P

Interpretation Introduction

(a)

Interpretation:

The reason for the measurement of aggrecan degradation by the release of glycosaminoglycan needs to be explained.

Concept introduction:

The carbohydrates are combined with the proteins. Enzyme behaves aggrecan and produces a molecule.Some destruction can observe by the aggrecan.

Answer 8

Interpretation Introduction

(b)

Interpretation:

The reason for the glycosaminoglycan release to not indicate the aggrecan degradation needs to be explained.

Concept introduction:

Glycosaminoglycan is also known as mucopolysaccharides which have a series of disaccharides. This series contains amino sugar and uronic sugar. Glycosaminoglycan is also written as GAGs.

Answer 9

Interpretation Introduction

(b)

Interpretation:

The reason for the glycosaminoglycan release to not indicate the aggrecan degradation needs to be explained.

Concept introduction:

Glycosaminoglycan is also known as mucopolysaccharides which have a series of disaccharides. This series contains amino sugar and uronic sugar. Glycosaminoglycan is also written as GAGs.

Answer 10

Interpretation Introduction

(c)

Interpretation:

The purpose of the control needs to be explained.

Concept introduction:

Enzyme behaves aggrecan and producesa molecule. Some destruction can observe by the aggrecan.

Answer 11

Interpretation Introduction

(c)

Interpretation:

The purpose of the control needs to be explained.

Concept introduction:

Enzyme behaves aggrecan and producesa molecule. Some destruction can observe by the aggrecan.

Answer 12

Interpretation Introduction

(d)

Interpretation:

The effect of adding IL-2 needs to be explained.

Concept introduction:

IL-2 is also known as interleukin which is a signaling molecule of the immune system.

Answer 13

Interpretation Introduction

(d)

Interpretation:

The effect of adding IL-2 needs to be explained.

Concept introduction:

IL-2 is also known as interleukin which is a signaling molecule of the immune system.

Answer 14

Interpretation Introduction

(e)

Interpretation:

The response of aggrecanase inhibitor when IL-2 is added needs to be explained.

Concept introduction:

IL-2 is also known as interleukin which is a signaling molecule of the immune system.

Answer 15

Interpretation Introduction

(e)

Interpretation:

The response of aggrecanase inhibitor when IL-2 is added needs to be explained.

Concept introduction:

IL-2 is also known as interleukin which is a signaling molecule of the immune system.

Answer 16

Interpretation Introduction

(f)

Interpretation:

The reason for aggrecan destruction in the control needs to be explained.

Concept introduction:

Enzyme behaves aggrecan and produces a molecule. Some destruction can observe by the aggrecan.

Answer 17

Interpretation Introduction

(f)

Interpretation:

The reason for aggrecan destruction in the control needs to be explained.

Concept introduction:

Enzyme behaves aggrecan and produces a molecule. Some destruction can observe by the aggrecan.

Answer 18

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Answer 19

Expert Solution & Answer

Answer 20

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Answer 21

Ch. 11 - Prob. 1P Ch. 11 - Prob. 2P Ch. 11 - Prob. 3P Ch. 11 - Prob. 4P Ch. 11 - Prob. 5P Ch. 11 - Prob. 6P Ch. 11 - Prob. 7P Ch. 11 - Prob. 8P Ch. 11 - Prob. 9P Ch. 11 - Prob. 10P

(a) Interpretation: The reason for the measurement of aggrecan degradation by the release of glycosaminoglycan needs to be explained. Concept introduction: The carbohydrates are combined with the proteins. Enzyme behaves aggrecan and produces a molecule.Some destruction can observe by the aggrecan.

Solution Summary: The author explains the reason for the measurement of aggrecan degradation by the release of glycosaminoglycan.

Concept explainers

(c)

Interpretation:

The purpose of the control needs to be explained.

Concept introduction:

Enzyme behaves aggrecan and producesa molecule. Some destruction can observe by the aggrecan.

(d)

Interpretation:

The effect of adding IL-2 needs to be explained.

Concept introduction:

IL-2 is also known as interleukin which is a signaling molecule of the immune system.

(e)

Interpretation:

The response of aggrecanase inhibitor when IL-2 is added needs to be explained.

Concept introduction:

IL-2 is also known as interleukin which is a signaling molecule of the immune system.

(f)

Interpretation:

The reason for aggrecan destruction in the control needs to be explained.

Concept introduction:

Enzyme behaves aggrecan and produces a molecule. Some destruction can observe by the aggrecan.

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Chapter 11 Solutions

(a) Interpretation: The reason for the measurement of aggrecan degradation by the release of glycosaminoglycan needs to be explained. Concept introduction: The carbohydrates are combined with the proteins. Enzyme behaves aggrecan and produces a molecule.Some destruction can observe by the aggrecan.

Solution Summary: The author explains the reason for the measurement of aggrecan degradation by the release of glycosaminoglycan.

Concept explainers

(a) Interpretation: The reason for the measurement of aggrecan degradation by the release of glycosaminoglycan needs to be explained. Concept introduction: The carbohydrates are combined with the proteins. Enzyme behaves aggrecan and produces a molecule.Some destruction can observe by the aggrecan.

(c) Interpretation: The purpose of the control needs to be explained. Concept introduction: Enzyme behaves aggrecan and producesa molecule. Some destruction can observe by the aggrecan.

(d) Interpretation: The effect of adding IL-2 needs to be explained. Concept introduction: IL-2 is also known as interleukin which is a signaling molecule of the immune system.

(e) Interpretation: The response of aggrecanase inhibitor when IL-2 is added needs to be explained. Concept introduction: IL-2 is also known as interleukin which is a signaling molecule of the immune system.

(f) Interpretation: The reason for aggrecan destruction in the control needs to be explained. Concept introduction: Enzyme behaves aggrecan and produces a molecule. Some destruction can observe by the aggrecan.

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Chapter 11 Solutions

(c)

Interpretation:

The purpose of the control needs to be explained.

Concept introduction:

Enzyme behaves aggrecan and producesa molecule. Some destruction can observe by the aggrecan.

(d)

Interpretation:

The effect of adding IL-2 needs to be explained.

Concept introduction:

IL-2 is also known as interleukin which is a signaling molecule of the immune system.

(e)

Interpretation:

The response of aggrecanase inhibitor when IL-2 is added needs to be explained.

Concept introduction:

IL-2 is also known as interleukin which is a signaling molecule of the immune system.

(f)

Interpretation:

The reason for aggrecan destruction in the control needs to be explained.

Concept introduction:

Enzyme behaves aggrecan and produces a molecule. Some destruction can observe by the aggrecan.