Chapter 11, Problem 30P

Now consider a mating between consanguineous people involving a recessive genetic disease. The figures that follow show the genotypes of these two people at four SNP loci (1–4).

 

a.	For which of these loci is it possible to obtain information about the linkage of the SNP to the disease gene? Explain your answer for each locus and describe any special conditions that may apply.
b.	For any of the loci for which the mating is potentially informative, how would you tell whether the child is the product of a recombinant or non recombinant gamete? (That is, how could you solve the phase problem?) Be as specific as possible.