Concept explainers
Choose the phrase from the right column that best fits the term in the left column.
a. DNA polymorphism | DNA elements composed of short tandemly repeated sequences |
b. phase | two different |
c. informative cross | arrangement of alleles of two linked genes in a diploid |
d. ASO | location on a chromosome |
e. SNP | a DNA sequence that occurs in two or more variant forms |
f. DNA fingerprinting | a short oligonucleotide that will hybridize to only one allele at a chose SNP locus |
g. SSR | detection of genotype at a number of unlinked highly polymorphic loci |
h. locus | allows identification of a gamete as recombinant or nonrecombinant |
i. compound heterozygote | all exons in a genome |
j. exome | individuals with two different mutations in the same gene |
a.
To determine:
The phrase that describes “DNA polymorphism” among the options given below:
1. DNA elements composed of short tandemly repeated sequences |
2. two different nucleotides appear at the same position in genomic DNA from different individuals |
3. arrangement of alleles of two linked genes in a diploid |
4. location on a chromosome |
5. a DNA sequence that occurs in two or more variant forms |
6. a short oligonucleotide that will hybridize to only one allele at a chose SNP locus |
7. detection of genotype at a number of unlinked highly polymorphic loci |
8. allows identification of a gamete as recombinant or nonrecombinant |
9. all exons in a genome |
10. individuals with two different mutations in the same gene |
Introduction:
DNA (deoxyribonucleic acid) is packaged in a chromosome as two spiraling strands. These two strands twist together to form a double helix structure.
Answer to Problem 1P
Correct answer:
DNA polymorphism: A DNA sequence that occurs in two or more variant forms
Explanation of Solution
DNA polymorphism refers to a DNA sequence that occurs in two or more alleles at a locus.
b.
To determine:
The phrase that describes “phase” among the options given below:
1. DNA elements composed of short tandemly repeated sequences |
2. two different nucleotides appear at the same position in genomic DNA from different individuals |
3. arrangement of alleles of two linked genes in a diploid |
4. location on a chromosome |
5. a DNA sequence that occurs in two or more variant forms |
6. a short oligonucleotide that will hybridize to only one allele at a chose SNP locus |
7. detection of genotype at a number of unlinked highly polymorphic loci |
8. allows identification of a gamete as recombinant or nonrecombinant |
9. all exons in a genome |
10. individuals with two different mutations in the same gene |
Introduction:
The term phase is also described as linkage phase. The occurrence of two dissimilar genes on same chromosome is defined as linkage.
Answer to Problem 1P
Correct answer:
Phase: Arrangement of alleles of two linked genes in a diploid
Explanation of Solution
The arrangement of the alleles of linked genes on two parental chromosomes referred to as the linkage phase.
c.
To determine:
The phrase that describes “informative cross” among the options given below:
1. DNA elements composed of short tandemly repeated sequences |
2. two different nucleotides appear at the same position in genomic DNA from different individuals |
3. arrangement of alleles of two linked genes in a diploid |
4. location on a chromosome |
5. a DNA sequence that occurs in two or more variant forms |
6. a short oligonucleotide that will hybridize to only one allele at a chose SNP locus |
7. detection of genotype at a number of unlinked highly polymorphic loci |
8. allows identification of a gamete as recombinant or nonrecombinant |
9. all exons in a genome |
10. individuals with two different mutations in the same gene |
Introduction:
The forms of genetic crossese are informative cross, testcross, backcross, monohybrid cross, and dihybrid cross.
Answer to Problem 1P
Correct answer:
Informative cross: Allows identification of a gamete as recombinant or nonrecombinant
Explanation of Solution
The genetic crosses that allow the identification of recombinant and nonrecombinant gametes are known as informative crosses.
d.
To determine:
The phrase that describes “ASO” among the options given below:
1. DNA elements composed of short tandemly repeated sequences |
2. two different nucleotides appear at the same position in genomic DNA from different individuals |
3. arrangement of alleles of two linked genes in a diploid |
4. location on a chromosome |
5. a DNA sequence that occurs in two or more variant forms |
6. a short oligonucleotide that will hybridize to only one allele at a chose SNP locus |
7. detection of genotype at a number of unlinked highly polymorphic loci |
8. allows identification of a gamete as recombinant or nonrecombinant |
9. all exons in a genome |
10. individuals with two different mutations in the same gene |
Introduction:
The full form of ASO is allele-specific oligonucleotide. Short deoxyribonucleic acid or ribonucleic acid polymers are defined as oligonucleotide.
Answer to Problem 1P
Correct answer:
ASO: A short oligonucleotide that will hybridize to only one allele at a chosen SNP locus
Explanation of Solution
ASO refers to short 20 to 40 base long oligonucleotides that will hybridize under specific conditions to only one of the two alleles at SNP locus.
e.
To determine:
The phrase that describes “SNP” among the options given below:
1. DNA elements composed of short tandemly repeated sequences |
2. two different nucleotides appear at the same position in genomic DNA from different individuals |
3. arrangement of alleles of two linked genes in a diploid |
4. location on a chromosome |
5. a DNA sequence that occurs in two or more variant forms |
6. a short oligonucleotide that will hybridize to only one allele at a chose SNP locus |
7. detection of genotype at a number of unlinked highly polymorphic loci |
8. allows identification of a gamete as recombinant or nonrecombinant |
9. all exons in a genome |
10. individuals with two different mutations in the same gene |
Introduction:
SNP is referred to as single nucleotide polymorphism. The differnce in the sequence of nucleotide between the living beings is described as polymorphism.
Answer to Problem 1P
Correct answer:
SNP: Two different nucleotides appear at the same position in genomic DNA from different individuals
Explanation of Solution
SNP refers to a single nucleotide locus with two naturally existing alleles described by single base pair substitution.
f.
To determine:
The phrase that describes “DNA fingerprinting” among the options given below:
1. DNA elements composed of short tandemly repeated sequences |
2. two different nucleotides appear at the same position in genomic DNA from different individuals |
3. arrangement of alleles of two linked genes in a diploid |
4. location on a chromosome |
5. a DNA sequence that occurs in two or more variant forms |
6. a short oligonucleotide that will hybridize to only one allele at a chose SNP locus |
7. detection of genotype at a number of unlinked highly polymorphic loci |
8. allows identification of a gamete as recombinant or nonrecombinant |
9. all exons in a genome |
10. individuals with two different mutations in the same gene |
Introduction:
DNA (deoxyribonucleic acid) fingerprinting refers to a technique that is generally utilized for forensic purposes.
Answer to Problem 1P
Correct answer:
DNA fingerprinting: Detection of genotype at a number of unlinked highly polymorphic loci
Explanation of Solution
In DNA fingerprinting, genotyping of multiple polymorphic loci provides information to identify people from their DNA.
g.
To determine:
The phrase that describes “SSR” among the options given below:
1. DNA elements composed of short tandemly repeated sequences |
2. two different nucleotides appear at the same position in genomic DNA from different individuals |
3. arrangement of alleles of two linked genes in a diploid |
4. location on a chromosome |
5. a DNA sequence that occurs in two or more variant forms |
6. a short oligonucleotide that will hybridize to only one allele at a chose SNP locus |
7. detection of genotype at a number of unlinked highly polymorphic loci |
8. allows identification of a gamete as recombinant or nonrecombinant |
9. all exons in a genome |
10. individuals with two different mutations in the same gene |
Introduction:
The full form of SSR is simple sequence repeats, and these repeats are also known as microsatellites.
Answer to Problem 1P
Correct answer:
SSR: DNA element composed of short tandemly repeated sequences:
Explanation of Solution
The loci of SSR consist of sequences of few bases that are repeated in tandem less than ten to more than hundred times.
h.
To determine:
The phrase that describes “locus” among the options given below:
1. DNA elements composed of short tandemly repeated sequences |
2. two different nucleotides appear at the same position in genomic DNA from different individuals |
3. arrangement of alleles of two linked genes in a diploid |
4. location on a chromosome |
5. a DNA sequence that occurs in two or more variant forms |
6. a short oligonucleotide that will hybridize to only one allele at a chose SNP locus |
7. detection of genotype at a number of unlinked highly polymorphic loci |
8. allows identification of a gamete as recombinant or nonrecombinant |
9. all exons in a genome |
10. individuals with two different mutations in the same gene |
Introduction:
Locus term is sometimes also defined as a gene. The term gene refers to the primary unit of heredity.
Answer to Problem 1P
Correct answer:
Locus: Location on a chromosome
Explanation of Solution
Locus refers to a designated location on a chromosome. Inside the nucleus, the molecule of DNA is packaged into a specific structure known as chromosome.
i.
To determine:
The phrase that describes “compound heterozygote” among the options given below:
1. DNA elements composed of short tandemly repeated sequences |
2. two different nucleotides appear at the same position in genomic DNA from different individuals |
3. arrangement of alleles of two linked genes in a diploid |
4. location on a chromosome |
5. a DNA sequence that occurs in two or more variant forms |
6. a short oligonucleotide that will hybridize to only one allele at a chose SNP locus |
7. detection of genotype at a number of unlinked highly polymorphic loci |
8. allows identification of a gamete as recombinant or nonrecombinant |
9. all exons in a genome |
10. individuals with two different mutations in the same gene |
Introduction:
The individual containing two types of alleles for a particular gene is described as the heterozygote.
Answer to Problem 1P
Correct answer:
Compound heterozygote: Individual with two different mutations in the same gene
Explanation of Solution
Compound heterozygote refers to an individual that contain two different mutant alleles of the same gene.
j.
To determine:
The phrase that describes “exome” among the options given below:
1. DNA elements composed of short tandemly repeated sequences |
2. two different nucleotides appear at the same position in genomic DNA from different individuals |
3. arrangement of alleles of two linked genes in a diploid |
4. location on a chromosome |
5. a DNA sequence that occurs in two or more variant forms |
6. a short oligonucleotide that will hybridize to only one allele at a chose SNP locus |
7. detection of genotype at a number of unlinked highly polymorphic loci |
8. allows identification of a gamete as recombinant or nonrecombinant |
9. all exons in a genome |
10. individuals with two different mutations in the same gene |
Introduction:
The term exome refer to coding parts of the genes. Genes are the primary functional and physical unit of heredity.
Answer to Problem 1P
Correct answer:
Exome: All exons in a genome
Explanation of Solution
Exome refers to the collection of all exons of all the genes and constitutes less than two percent of whole-genome DNA.
Want to see more full solutions like this?
Chapter 11 Solutions
Genetics: From Genes to Genomes
- This Manhattan plot shows the results of a GWAS investigation of prostate cancer risk. Select which of the statements below could be TRUE based on the data provided. Select ALL that apply 4, Chromosome а. The Y axis is the strength of association between prostate cancer and the variant. b. The spike at the end of Chr 6 indicate the presence of a low risk allele for breast cancer. O c. There are 6 SNPS that are associated with increased risk for prostate cancer. O d. The low heritability of prostate cancer makes GWAS an excellent tool for understanding prostate cancer risk. O e. The X axis represents any loci in the genome with variation. -Hog10 (P)arrow_forwardDefine the following terms: a. histone b. heterochromatin c. spermine d. intergenic sequences e. tandem repeatsarrow_forwardAltered chromosome structure can drastically affect an individual organism’s phenotype. However, some types of chromosomal rearrangements are more likely to be harmful than others. Categorize the following types of rearrangements from MOST LIKELY to be harmful to LEAST LIKELY to be harmful. A. reciprocal translocation, deletion, translocation B. deletion, translocation, inversion C. inversion, translocation, reciprocal translocation D. translocation, inversion, duplicationarrow_forward
- In references to the "alpha-globin gene locus" or "beta-globin gene locus", the term "locus" means A a chromosome region with a cluster of related globin protein genes. B a geographical region where a genetic disease like sickle cell anemia is common. the location, in this case red blood cells, where a mutant phenotype is manifested D. a duplicated, ancestral gene. an alpha, or a beta-globin protein with a single amino acid change.arrow_forwardUsing figure 1 and the following background information answer the following questions. Identification of the genetic cause of hornlessness in cattle has been the subject of intensive genetic and genomic research, culminating in the nomination of two different candidate neomutations on cattle chromosome 1 that are predicted to have arisen 500-1,000 years ago: a complex allele of Friesian origin (PF), an 80,128 base pair (bp) duplication (1909352–1989480 bp), and a second, simple allele of Celtic origin (PC) corresponding to a duplication of 212 bp (chromosome 1 positions 1705834–1706045) in place of a 10-bp deletion (1706051–1706060)We report the use of genome editing using transcription activator-like effector nucleases (TALENs) to introgress the putative PC POLLED allele into the genome of bovine embryo fibroblasts to try and produce a genotype identical to what is achievable using natural mating, but without the attendant genetic drag and admixture. In our previous studies, we…arrow_forwardChromosome translocations include: A. Alterations in which the genetic material remains the same but rearranged B. Alterations in which the total amount of genetics information increases C. Alterations in which the total amount of genetics information decreases D. Variations in the chromosome numberarrow_forward
- Aliens with orang eye color allele (o) is recessive to the dominant black eye color allele (O). The locus of the orange gene from 10 pure breed orange eyes aliens and 10 pure breed black eyes aliens. You notice a difference in the DNA sequence linked to each allele of the orange gene and you decide to use it as a physical marker to follow recombination between this sequence linked to the orange gene. These sequences consist of short tandem repeat (STR) with two different number of repeats, each associated with one of the two orange gene alleles. a PCR test distinguishes the 10 repeat STR and the 6 repeat STR associated with the O and o alleles respectively. Using primers on each side of the STRs you can amplify by PCR this sequence and visualizing the size of the 10 repeat and 6 repeat STRs in an electrophoresis gel. You can follow the two STR sequences (10 and 6 repeats) linkage and recombination frequencies with the orange gene locus. The black eye aliens yield a PCR fragment that is…arrow_forwardA pair of paralogous repeats, A and B, have 96% sequence similarity and therefore can promote non-allelic homologous recombination (NAHR). They exist in four possible arrangements in a genome, illustrated below as arrangements 1 – 4. What is the result of NAHR between repeats A and B in arrangement 1? A.Translocation between chromosomes 1 and 2 resulting in monocentric chromosomes B.Deletion or duplication of the region between A and B C.Translocation between chromosomes 1 and 2 resulting in acentric and dicentric chromosomes D.Inversion of the region between A and Barrow_forwardSelect the best process listed below for each of the following statements. Note that you need to know that the sequence of amino acids directly reflects the sequence of genes that coded for their placement. Homologous sets of genes ABCDEF and aBCdEF are located on - vnonhomologous chromosomes. Crossing over between them is suppressed because their locations are the result of this. Homologous sets of genes ABCDEF and AEDCBF are located on homologous chromosomes. A small region of a protein from three species is sequenced and found to be as follows: species X is alanine, glycine, glycine, threonine, alanine v species Y is alanine, glycine, threonine, alanine species Z is alanine, glycine, glycine, threonine, alanine The difference in the amino acid sequence of species Y is most likely due to this. a. Inversion b. Deletion A small region of a protein from three species is sequenced and found to be as follows: c. Gene duplication d. Translocation e. Insertion species X is alanine, glycine,…arrow_forward
- Using the figure and the following background information answer the following questions about the figure Background: Identification of the genetic cause of hornlessness in cattle has been the subject of intensive genetic and genomic research, culminating in the nomination of two different candidate neomutations on cattle chromosome 1 that are predicted to have arisen 500-1,000 years ago: a complex allele of Friesian origin (PF), an 80,128 base pair (bp) duplication (1909352-1989480 bp), and a second, simple allele of Celtic origin (PC) corresponding to a duplication of 212 bp (chromosome 1 positions 1705834-1706045) in place of a 10-bp deletion (1706051-1706060)We report the use of genome editing using transcription activator-like effector nucleases (TALENs) to introgress the putative PC POLLED allele into the genome of bovine embryo fibroblasts to try and produce a genotype identical to what is achievable using natural mating, but without the attendant genetic drag and admixture. In…arrow_forwardDefine the following terms:a. histonesb. heterochromatinc. euchromatind. intergenic sequencese. tandem repeatsarrow_forwardA research team interested in mapping human genes discovered a new restriction length polymorphism (RFLP). The nature of the polymorphism is shown in the figure below. a) They test the RFLP in a family with the pedigree below. The individuals colored blue are affected by hemophilia, a blood-clotting disease. On what chromosome is the RFLP found?arrow_forward
- Human Heredity: Principles and Issues (MindTap Co...BiologyISBN:9781305251052Author:Michael CummingsPublisher:Cengage Learning