Genetics: From Genes to Genomes
6th Edition
ISBN: 9781259700903
Author: Leland Hartwell Dr., Michael L. Goldberg Professor Dr., Janice Fischer, Leroy Hood Dr.
Publisher: McGraw-Hill Education
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Chapter 10, Problem 28P
Summary Introduction
a.
To determine:
The subunit structure of hemoglobin molecules marked X, Y, and Z.
Introduction:
Hemoglobin is an essential part of RBCs as it delivers oxygen to all the parts of the human body.
Summary Introduction
b.
To determine:
The normal condition that should increase the hemoglobin percentage in a newborn that is HbZ.
Introduction:
Hemoglobin refers to a protein in RBCs that carries oxygen throughout the body. The hemoglobin is made up of subunits known as heme, which gives the blood its red color.
Summary Introduction
c.
To determine:
The normal condition that should increase the hemoglobin percentage in an adult that is HbY.
Introduction:
A normal adult hemoglobin molecule consists of two alpha globins and two beta globins. Each globin surrounds an iron-containing a small molecular structure called heme group.
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Students have asked these similar questions
What will be the effect of the following changes to the protein structure of hemoglobin and its function?
A. Replacement of the proximal histidine residue at the 8thposition of the F helix by asparagine.
B. A phenylalanine to proline mutation resulting in decreased cooperativity of the polypeptide chains.
C. Replacement of a nonpolar amino acid in the interior of the protein to a hydrophilic amino acid.
Below is the DNA base sequence for the normal protein for normal hemoglobin and the base sequence for (abnormal) sickle cell hemoglobin:
Normal GGG CTT CTT TTT
Sickle GGG CAT CTT TTT
A)Transcribe and translate the normal and sickle cell DNA.
B)Identify this as a point or frameshift mutation. Explain.
Actually my head was confused in case (c). Is the answer just Hb Providence ? or Hb Cowtown and Hb Providence both?
Chapter 10 Solutions
Genetics: From Genes to Genomes
Ch. 10 - Prob. 1PCh. 10 - List three independent techniques you could use to...Ch. 10 - Figure 10.2a has numbers indicating the...Ch. 10 - Which of the enzymes from the following list would...Ch. 10 - Prob. 5PCh. 10 - a. What sequence information about a gene is...Ch. 10 - Why do geneticists studying eukaryotic organisms...Ch. 10 - Consider three different kinds of human libraries:...Ch. 10 - The human genome has been sequenced, but we still...Ch. 10 - This problem investigates issues encountered in...
Ch. 10 - For the sake of simplicity, Fig. 10.4 omitted one...Ch. 10 - Give two different reasons for the much higher...Ch. 10 - Using a cDNA library, you isolated two different...Ch. 10 - The figure that follows shows part of a modified...Ch. 10 - In Problem 14, cDNAs F and G could not be found in...Ch. 10 - Fig. 10.10 presents a model for exon shuffling in...Ch. 10 - An interesting phenomenon found in vertebrate DNA...Ch. 10 - a. If you found a zinc-finger domain which...Ch. 10 - Prob. 19PCh. 10 - In the human immune system, so-called B cells can...Ch. 10 - Chimpanzees have a set of hemoglobin genes very...Ch. 10 - Complete genome sequences indicate that the human...Ch. 10 - On your computers browser, view the page accessed...Ch. 10 - Prob. 24PCh. 10 - Prob. 25PCh. 10 - Certain individuals with mild forms of...Ch. 10 - The 1 and 2 genes in humans are identical in their...Ch. 10 - Prob. 28P
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