Genetics: From Genes to Genomes
Genetics: From Genes to Genomes
6th Edition
ISBN: 9781259700903
Author: Leland Hartwell Dr., Michael L. Goldberg Professor Dr., Janice Fischer, Leroy Hood Dr.
Publisher: McGraw-Hill Education
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Chapter 10, Problem 14P

The figure that follows shows part of a modified screen shot of part of the human genome as displayed on the UCSC Genome Browser. A through G map the sequences within individual cDNA clones to the genome sequence. Refer to the key in Fig. 10.3 if you need help in interpreting this diagram. Pay close attention to the vertical widths of the icons indicating exons.

Chapter 10, Problem 14P, The figure that follows shows part of a modified screen shot of part of the human genome as

  1. How many annotated genes do you think are present in this region of the human genome?

  2. For all annotated genes in this region, indicate whether they are transcribed in the direction from centromere to telomere or from telomere to centromere.

  3. How many promoters are suggested by the data? Approximately where are these promoters located?

  4. How many different proteins are encoded by the DNA sequences in this region?

  5. What is unusual about this region of the human genome?

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calculate the questions showing the solution including variables,unit and equations all the questiosn below using the data a) B1,   b) B2,   c) hybrid rate constant (1) d) hybrid rate constant (2) e) t1/2,dist f) t1/2,elim   g) k10 h) k12 i) k21 j) initial concentration (C0)   k) central compartment volume (V1) l) steady-state volume (Vss)   m) clearance (CL)  AUC (0→10 min) using trapezoidal rule n)  AUC (20→30 min) using trapezoidal rule o) AUCtail (AUC360→∞)   p) total AUC (using short cut method) q) volume from AUC (VAUC)
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Genome Annotation, Sequence Conventions and Reading Frames; Author: Loren Launen;https://www.youtube.com/watch?v=MWvYgGyqVys;License: Standard Youtube License