Microbiology Fundamentals: A Clinical Approach
3rd Edition
ISBN: 9781260163698
Author: Cowan
Publisher: MCG
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Textbook Question
Chapter 1, Problem 19Q
When a hypothesis has been thoroughly supported by long-term study and data, it is considered
- a. a law.
- b. a speculation.
- c. a theory.
- d. proven.
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Digoxin: Intravenous Bolus - Two Compartment Model
Drug
Digoxin
Route:
IV Bolus
Dose:
0.750 mg
Plasma Concentration Time Profile
Beta
Alpha
Time (hrs)
Conc (ng/ml)
LN
(ng/ml)
LN
(ng/ml)
LN
0.00
#NUM!
#NUM!
#NUM!
0.10
12.290
2.509
#NUM!
#NUMI
0.60
6.975
1.942
#NUM!
#NUMI
1.00
4.649
1.537
#NUM!
#NUMI
2.00
2.201
0.789
#NUM!
#NUM!
3.00
1.536
0.429
#NUM!
#NUM!
4.00
1.342
0.294
#NUM!
#NUM!
5.00
1.273
0.241
#NUM!
#NUMI
6.00
1.238
0.213
#NUM!
#NUM!
7.00
1.212
0.192
#NUM!
#NUM!
8.00
1.188
0.172
#NUMI
#NUM!
9.00
1.165
0.153
#NUM!
#NUMI
10.00
1.143
0.134
#NUMI
#NUM!
11.00
1.122
0.115
#NUM!
12.00
1.101
0.096
#NUMI
13.00
1.080
0.077
#NUMI
16.00
1.020
0.020
#NUMI
24.00
0.876
-0.132
#NUMI
Pharmacokinetic Parameters
Parameter
Value
Alpha
B
Beta
Units
ng/ml
hr-1
ng/ml
hr-1
CO
ng/ml
H.C
AUC
ng x hr/ml
Vc
Vbeta
Vss
C
L/hr
TK (alpha)
hr
TX (beta)
days
5+
F3
F4
F5
0+
F6
F7
%
6
95
14
#3
29
&
t
F8
F9
FW
EW
Linuron, a derivative of urea, is used as an herbicide. Linuron serum levels were measured in 4Kg
rabbits following a bolus IV injection of 10mg/kg.
Time (minutes)
Serum Linuron Levels (ug/ml)
following IV dose
10
15.48
20
8.60
30
5.90
45
3.78
60
2.42
90
1.49
120
0.93
180
0.60
240
0.41
300
0.29
360
0.22
Analyze this data and perform the necessary calculations to determine the following pharmacokinetic
parameters from the IV data: (5 points per parameter, 24 parameters/variables ■ 120 points
possible). You do NOT need to submit graphs or data tables.
Give the terminal regression line equation and R or R² value:
Give the x axis (name and units, if any) of the terminal line:
Give the y axis (name and units, if any) of the terminal line:
Give the residual regression line equation and R or R² value:
Give the x axis (name and units, if any) of the residual line:
Give the y axis (name and units, if any) of the residual line:
Chapter 1 Solutions
Microbiology Fundamentals: A Clinical Approach
Ch. 1.1 - List the various types of microorganisms that can...Ch. 1.1 - Describe the role and impact of microbes on the...Ch. 1.1 - Explain the theory of evolution and why it is...Ch. 1.1 - Explain the ways that humans manipulate organisms...Ch. 1.1 - Summarize the relative burden of human disease...Ch. 1.1 - Differentiate among bacteria, archaea, and...Ch. 1.1 - Identify an acellular infectious agent that is...Ch. 1.1 - Compare and contrast the relative sizes of the...Ch. 1.1 - Q.Can you think of a logical reason that a microbe...Ch. 1.1 - NCLEX PREP 1. For which of the following disease...
Ch. 1.2 - Make a time line of the development of...Ch. 1.2 - List some recent microbiology discoveries of great...Ch. 1.2 - Identify the important features of the scientific...Ch. 1.3 - Name the four main families of biochemicals.Ch. 1.3 - Provide examples of cell components made from each...Ch. 1.3 - Differentiate among primary, secondary, tertiary,...Ch. 1.3 - List the three components of a nucleotide.Ch. 1.3 - Name the three nitrogen bases of DNA and RNA.Ch. 1.3 - Prob. 17AYPCh. 1.3 - Recall three characteristics common to all cells.Ch. 1.3 - Q. Use context in the paragraph above to deduce...Ch. 1.3 - Prob. 2NPCh. 1.4 - Differentiate among the terms nomenclature,...Ch. 1.4 - Create a mnemonic device for remembering the...Ch. 1.4 - Correctly write the binomial name for a...Ch. 1.4 - Draw a diagram of the three major domains.Ch. 1.4 - Explain the difference between traditional and...Ch. 1 - Prob. 1QCh. 1 - Name six types of microorganisms that we are...Ch. 1 - Defend the argument that a web of life is a more...Ch. 1 - Which of the following is a macromolecule that...Ch. 1 - Prob. 5QCh. 1 - Imagine a way you might design a drug to destroy...Ch. 1 - Prob. 7QCh. 1 - Provide an argument about why metabolic...Ch. 1 - Provide a possible interpretation of the finding...Ch. 1 - DNA leads to RNA which can lead to the creation of...Ch. 1 - Compare and contrast the RNA molecule with the DNA...Ch. 1 - Suggest an argument for why eukaryotic cells have...Ch. 1 - Prob. 13QCh. 1 - Defend or refute this statement: Microbes intend...Ch. 1 - Coevolution is a term describing the influence...Ch. 1 - Which of the following processes can be the result...Ch. 1 - Speculate about why scientists believe there are...Ch. 1 - Prob. 18QCh. 1 - When a hypothesis has been thoroughly supported by...Ch. 1 - Defend the use of complicated-sounding names for...Ch. 1 - Identify the most important component of the...Ch. 1 - Figure 1.2 Look at the red bat (the time that...
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