Your friend's genetic test revealed that they have a rare mutation - they lack the glycotransferase responsible for adding the terminal fucose molecule to the oligosaccharide on the surface of red blood cells. What is the consequence for a blood transfusion - which blood groups can they receive donations from, if any? Why? Although they lack the terminal fucose normally found on the surface of red blood cells, can you make any predictions as to wheter they also have or lack the Galactose or GalNAc found on A or B blood types? Your friend suggested a simpler way to test for this type of mutation. They have suggested taking a Fucosidase (a type of glycosidase) and mutating it so that the active site was no longer functional - they claim this would endow the protein with the properties of a lectin. Does their claim make any sense

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Hematology

Hematology is the branch of biology. Hematology is the medical field that deals with the treatment of blood disorders and cancers, such as hemophilia, leukemia, lymphoma, and sickle-cell anemia. Hematologists and hematopathologists are medical professionals who specialize in illnesses of the blood and its components.