The gamma and beta subunits that make up fetal and adult hemoglobin, respectively, differ in a His143 mutation to a Ser143 in the fetal hemoglobin - resulting in a higher affinity for oxygen in the fetal hemoglobin. True or False The result of this mutation results in the protein binding BPG with lower affinity.
Gene Interactions
When the expression of a single trait is influenced by two or more different non-allelic genes, it is termed as genetic interaction. According to Mendel's law of inheritance, each gene functions in its own way and does not depend on the function of another gene, i.e., a single gene controls each of seven characteristics considered, but the complex contribution of many different genes determine many traits of an organism.
Gene Expression
Gene expression is a process by which the instructions present in deoxyribonucleic acid (DNA) are converted into useful molecules such as proteins, and functional messenger ribonucleic (mRNA) molecules in the case of non-protein-coding genes.
Would this mutation result in protein binding BPG with lower affinity?
BPG is 2,3-bisphosphoglycerate, which produced in the respiring tissue as a byproduct of glucose metabolism.
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