Answered: Аpaf1 Figure Q18-1 Appearance of paws…

Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

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Question

In contrast to their similar brain abnormalities,
newborn mice deficient in Apaf1 or caspase-9 have dis-
tinctive abnormalities in their paws. Apaf1-deficient mice
fail to eliminate the webs between their developing digits,
whereas caspase-9-deficient mice have normally formed
digits (Figure Q18–1). If Apaf1 and caspase-9 function in
the same apoptotic pathway, how is it possible for these
deficient mice to differ in web-cell apoptosis?

Аpaf1
Figure Q18-1 Appearance of paws in
Apaf1+ and Caspg- newbom mice
relative to normal newborn mice (Problem
18-6). (From H. Yoshida et al., Col 94:739-
750, 1998. With permission from Elsevier.)
Casp9

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