One of the treatments for sickle cell anemia is hydroxyurea, which is known to induce the expression and production of fetal hemoglobin through a poorly defined mechanism. Explain how the increased expression of fetal hemoglobin can be a useful treatment for sickle cell anemia.
One of the treatments for sickle cell anemia is hydroxyurea, which is known to induce the expression and production of fetal hemoglobin through a poorly defined mechanism. Explain how the increased expression of fetal hemoglobin can be a useful treatment for sickle cell anemia.
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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One of the treatments for sickle cell anemia is hydroxyurea, which is known to induce the expression and production of fetal hemoglobin through a poorly defined mechanism. Explain how the increased expression of fetal hemoglobin can be a useful treatment for sickle cell anemia.
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Step 1
The most important mutation is the third one where serine replaces histidine. Whereas histidine is positively charged and binds to negatively charged lons of 2,3 BPG serine is neutral and so less of fetal hemoglobin binds to 2,3 BPG so more of oxygen binds to it resulting in higher oxygen affinity Mostly fetal hemoglobin is replaced by adult hemoglobin at birth.
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