Question 23You discovered a potential new drug molecule, which binds to its target with a binding free energyof -41.0 kJ/mol at 37 °C. You are performing additional experiments in order to improve thebinding affinity of the drug. Select all of the possible modifications that could improve binding.O A phenyl group at another site of the drug increases the association constant by a factor of 5.You engineer a new hydrogen bond to be formed between the drug and the target.The addition of an alcohol function in another side of the drug molecule reduces the dissociation constantof the drug-target complex by a factor of 10.O The addition of a methyl group at one specific site of the drug mctecule results in a binding free energy of-40.5 kJ/mol.

Binding free energy is defined as the sum of all the intermolecular interactions present between the…

You discovered a potential new drug molecule, which binds to its target with a binding free energy of -41.0 kJ/mol at 37 °C. You are performing additional experiments in order to improve the binding affinity of the drug. Select all of the possible modifications that could improve binding. O A phenyl group at another site of the drug increases the association constant by a factor of 5. O You engineer a new hydrogen bond to be formed between the drug and the target. O The addition of an alcohol function in another side of the drug molecule reduces the dissociation constant of the drug-target complex by a factor of 10. O The addition of a methyl group at one specific site of the drug moecule results in a binding free energy of -40.5 kJ/mol.

You discovered a potential new drug molecule, which binds to its target with a binding free energy of -41.0 kJ/mol at 37 °C. You are performing additional experiments in order to improve the binding affinity of the drug. Select all of the possible modifications that could improve binding. O A phenyl group at another site of the drug increases the association constant by a factor of 5. O You engineer a new hydrogen bond to be formed between the drug and the target. O The addition of an alcohol function in another side of the drug molecule reduces the dissociation constant of the drug-target complex by a factor of 10. O The addition of a methyl group at one specific site of the drug moecule results in a binding free energy of -40.5 kJ/mol.

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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