In the cases where binding potency of the ligand A is determined in a functional assay in the presence of another molecule L, e.g substrate or agonist, potency of the ligand L is characterized by a parameter of EC50. Define the relationship between EC50 for the ligand A and KD for the molecule L. Most of the time EC50= KD EC50> KD EC50< KD EC50 becomes smaller as (L) becomes larger. High EC50 indicates high potency of ligand L.
In the cases where binding potency of the ligand A is determined in a functional assay in the presence of another molecule L, e.g substrate or agonist, potency of the ligand L is characterized by a parameter of EC50. Define the relationship between EC50 for the ligand A and KD for the molecule L. Most of the time EC50= KD EC50> KD EC50< KD EC50 becomes smaller as (L) becomes larger. High EC50 indicates high potency of ligand L.
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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In the cases where binding potency of the ligand A is determined in a functional assay in the presence of another molecule L, e.g substrate or agonist, potency of the ligand L is characterized by a parameter of EC50. Define the relationship between EC50 for the ligand A and KD for the molecule L.
- Most of the time EC50= KD
- EC50> KD
- EC50< KD
- EC50 becomes smaller as (L) becomes larger.
- High EC50 indicates high potency of ligand L.
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