Which statements are true? Explain why or why not.1 The chemical carcinogen dimethylbenz[a]anthra-cene (DMBA) must be an extraordinarily specific mutagensince 90% of the skin tumors it causes have an A-to-T alter-ation at exactly the same site in the mutant Ras gene.2 In the cellular regulatory pathways that controlcell growth and proliferation, the products of oncogenesare stimulatory components and the products of tumorsuppressor genes are inhibitory components.3 Cancer therapies directed solely at killing the rap-idly dividing cells that make up the bulk of a tumor areunlikely to eliminate the cancer from many patients.4 The main environmental causes of cancer are theproducts of our highly industrialized way of life such aspollution and food additives.

Q: 127. Whicn of the following statement concerning the regulator gene (i) associated with the lac…

A: Answer- Lac operon operates in E.coli bacteria. It contains many set of genes arranged in a series…

Q: Relative Relative H3/H4 Acetylation Relative H3 Acetylation H4 Acetylation DON -4Kb -3Kb -2Kb -1Kb…

A: DNA is responsible for carrying genetic information in cells. DNA is packaged into condensed form…

Q: The lac operon consists of three structural genes, lacZ, lacY and lacA that are transcribed as a…

A: ii) LacP is called the promoter gene of lac operon.

Q: d. What does ‘transfection’ mean? e. What are ‘single clones’ and how did various single clones…

A: de novo DNA methylation is the addition of methyl groups to specific sites in the promoter region of…

Q: Part 3C: Below is data from a pedigree trace of patients affected with mouse model of pancreatic…

A: Answer  The mode of inheritance shown in the above pedigree is of autosomal recessive

Q: The GA(T>C)A mutation in the Duffy promoter impacted expression of Duffy in the following cell…

A: The promoter is the region where the RNA polymerase binds during the transcription i.e. synthesis of…

Q: TP53 encodes the p53 tumor suppressor gene and is the most mutated gene in cancer with 50% of…

A: Any abnormality in chromosome structure during G1 phase cell cycle is captured by the protein called…

Q: The lac operon consists of three structural genes, lacZ, lacY and lacA that are transcribed as a…

A: Lac operon has *3 structural genes- lacZ, lacY, lacA *promoter, *operator, *terminator, *regulator.

Q: they argued that promoter switching may be correlated with cancer development and progression…

A: A DNA (deoxyribonucleic acid) sequence where the protein binds and initiates the transcription of…

Q: P₁0 ORF1 t₁ ORF2 ORF3 t₂ The diagram above illustrates an operon that is regulated by the RepR…

A: An operon is a group of genes and the regulatory elements that regulate the expression of those…

Q: 1. You are stuaying regulation of peri gene expi amounts of Per1 mRNA and protein in normal cells…

A: PER1 transcription is regulated by protein interactions with its five E-box and one D-box elements…

Q: The human genes that convey a susceptibility to hereditary nonpolyposis colorectal cancer are genes…

A: Lynch syndrome, also known as hereditary nonpolyposis colorectal cancer (HNPCC), is a genetic…

Q: A knockout mouse with an ablated PRNP gene is injected with exogenous prions. Which of the following…

A: Option e Spongiform transformation of brain

Q: Which of the following molecules is designed to deliver drugs to the body cells? O a. Proteasome O…

A: "Since you have asked multiple questions, according to Bartleby's guidelines we are eligible to…

Q: 5. Which of the following modification associated with cance acetylation of TSG O none of the above…

A: A disease condition that involves the uncontrollable growth of some cells is defined by the term…

Q: 3). Consider the four mutations (i-iv) described below: i. One of the mutations causing cystic…

A: A mutation is a permanent change in the DNA sequence of an organism's genome. Mutations can occur…

Q: The diagram below shows the normal sequence of a particular protein, along with several mutant…

A: Original Sequence: Met Gly-Glu-The-Lys-Val-Val- -ProMutant Sequence: Met-GlyMutation Description: In…

Q: 1. For each of the following genes, categorize them as a tumor suppressor gene or a protooncogene.…

A: Bcl-2 gene is a protooncogene.The Bcl-2 can act as a barrier to apoptosis and and facilitate the…

Q: Select from the drop-down menu which type of regulation is occurring in each case. The Ixb12 gene…

A: Gene regulation is a mechanism of controlling the function of gene and it's associated mRNA and…

Q: A mutated form of protein p5x is found in patients with squamous cell carcinoma. In vitro studies…

A: A gene that produces a protein that is essential for regulating cell division and death and is…

Q: P+OcZ-Y+A+// P¬O+Z+Y+A+ i) The lac operon consists of three structural genes, lacZ, lacY and lacA.…

A: The lactose operon (also known as the lac operon) is a set of genes that are specific for the uptake…

Q: Explain the anti-apoptotic role of telomerase and telomeres. In which cell type telomerase is…

A: Apoptosis is the programmed cell death. It is used to remove unwanted cells from the body for…

Q: . Partial diploid forms of E. coli were created, each of which contained a com- plete lactose operon…

A: Lac operon is composed of lacI, P, lacO, lacZ, lacY and lacA genes. Regulatory genes are lacI, P and…

Q: ''The chemical carcinogen dimethylbenz[a]anthra-cene (DMBA) must be an extraordinarily specific…

A: Abnormal growth of skin cells when exposed to sunlight causes skin cancer. They are originated from…

Q: many cancers have mutations in more than one of these genes how could this happen. how did a single…

A: Cancer or tumor results when there is a normal cell division and there is no control on the cell…

Q: Would the function of KRAS gene be lost or gained in MDA-MB-231 breast cancer derived cells? Please…

A: KRAS gene is a gene present on the short arm of chromosome 12 that is responsible for the formation…

Q: Refer to the experimental approach (i.e., very briefly describe) and give the results AND…

A: (A) MicroRNA-25-3p (Mir-25-3 p) levels were measured in malignant and normal surrounding tissue…

Q: GQ8

A: The question is asking us to understand the effect of methylation of genes in prostate cancer cells…

Q: Describe error prone polymerases and the process of translesion synthesis (TLS). In regards to tumor…

A: Translesion synthesis (TLS) is a method of overcoming stopped replication in which particular…

Q: . Explain why mutations in oncogenes are generally dominant while those in tumor suppressor genes…

A: Proto-oncogenes and tumour suppressor genes are two types of gene essential for the control of cell…

Q: 2. Assume you have identified a new operon in bacteria (which you call the suc operon) that encodes…

A: The gene expression in prokaryotes is under the control of operon system in which the transcription…

Q: - In some tumor-suppressor genes like p53 and ras-oncogene, oxidative damage has been commonly…

A: p53 could be a tumor suppressor macromolecule that regulates the cell cycle and therefore functions…

Q: Write TRUE or FALSE. If false, write the word/s that make(s) the statement incorrect. 1.Metabolic…

A: Since you have asked multiple questions, we will slove the first question for you. If you want any…

Q: Can the compound cause expression for each gene.

A: Since you have asked multiple question, we will solve the first question for you. If you want any…

Q: Question 22 What effect would you expect methylation of the CG sites in IAP to have transcription of…

A: Transcription is a fundamental biological process that involves the synthesis of RNA molecules from…

Q: 27 of 41 Mutations in two important cancer-critical genes, encoding p53 and Rb, respectively, are…

A: Normal cells in cancer are continuously transformed into the tumour or malignant cells due to a…

Q: Define about this- Cancer Cells Contain GeneticDefects Affecting Genomic Stability ?

A: Cancer is a condition when a few of the body's cells grow out of control and migrate to other bodily…

Q: [PTG. Explain the mechanistic steps whether the expression of beta-galactosidase (Z) and permease…

A: In case of ii) or second merodiploid the mutation in the repressor in the chromosomal DNA ( the part…

Q: rowth medium contain. ophosphate expression of the lac op

A: Introduction: The lac operon is a genetic control element found in bacteria that regulates the…

Q: 5. discuss different components and types of epigenetic gene regulation 6. define mutation and…

A: Mutation occurs when the base pair sequence of our DNA changes as a result of numerous environmental…

Q: 2. You are studying the regulation of the lactose operon in Escherichia coli, by measuring…

A: The lac operon is responsible for the entry and metabolism of lactose in E. coli as well as most…

Q: The answer did not address why most cancer mutations occur upstream of MAPK (ie. RAS (10-20% NRAS…

A: RAS protein is monomeric G protein , it will belongs in the GTPase super family of intracellular…

Q: Even though cancer genomes are overall hypomethylated, explain in detail some genes are…

A: introduction: The study of changes in gene expression and DNA sequencing between cancer cells and…

Q: . Explain how the actions of the lac operon are different from the trp operon.

A: An operon is a cluster of genes that are transcribed together to give a single messenger RNA (mRNA)…

Q: it and answer the following questions. Recent studies showing a correlation between the levels of…

A: Cytosine is one of the four nucleobases found in DNA and RNA, along with adenine, guanine, and…

Q: The human CFTR gene encodes a chloride ion channel; loss of function mutations in this gene cause…

A: In order to ascertain the mutation that is most probable to lead to the inability of the mutant…

Cell Signaling

It allows cells to perform various cellular activities, coordinate, and interact with other cells. All cells of an organism receive signals from their environments and respond accordingly. Even the unicellular eukaryotes receive signals secreted by other cells and respond. In the case of yeast, mating takes place by signaling between the yeast cells. Communication by cell signaling in a multicellular organism has become a vast and important part of various fields of biology.