TP53 encodes the p53 tumor suppressor gene and is the most mutated gene in cancer with 50% of cancers having a mutated form. Given a lifetime risk of developing cancer of 42%, estimate the number of 300 million people who will have a TP53 mutation in their lifetime. Is a background mutation rate of 10-10 per base per generation compatible with this result? The TP53 gene is 25,772 bases long.

TP53 encodes the p53 tumor suppressor gene and is the most mutated gene in cancer with 50% of cancers having a mutated form. Given a lifetime risk of developing cancer of 42%, estimate the number of 300 million people who will have a TP53 mutation in their lifetime. Is a background mutation rate of 10-10 per base per generation compatible with this result? The TP53 gene is 25,772 bases long.

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter8: The Structure, Replication, And Chromosomal Organization Of Dna

Section8.4: The Watson-crick Model Of Dna Structure

Problem 2GR

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