Which of the following best indicates a reason why Hisneeds to be a good proton donor (not acceptor) in the catalytic triad mechanism? So that it can create the alkoxide ion. So that it can create a hydroxyde ion. None of the other options is suitable because His's only role is to be a proton acceptor. So that the first product forms and leaves with the correct number of H's. So that it can stabilize the transition state.

Biochemistry
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ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
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Chapter1: Biochemistry: An Evolving Science
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Which of the following best indicates a reason why Hisneeds to be a good proton donor (not acceptor) in the catalytic triad mechanism?

  • So that it can create the alkoxide ion.
  • So that it can create a hydroxyde ion.
  • None of the other options is suitable because His's only role is to be a proton acceptor.
  • So that the first product forms and leaves with the correct number of H's.
  • So that it can stabilize the transition state.
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