We learned that three different amino acid transformations of PLP-dependent enzymes can result from different conformations of the PLP-amino acid imine adduct in the active site. Starting from the PLP adduct of (S)-serine, show mechanisms for a) Decarboxylation of serine b) Racemization of serine c) Conversion of serine to glycine and formaldehyde.

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Mitochondrial Mutations

A mitochondrion is a cellular organelle that serves as the site for cellular respiration and energy production (ATP or Adenosine Triphosphate). It is a double-membrane-bound organelle and is only present in eukaryotic cells.