cytosol but those without this substance have concentrations of up to 50uM in the cytosol by the time they die. What does this tell you about the function of the isolated substance, OmpF, which you suspected from the start was related to quinolone resistance? How is the OmpF structure optimized for this function? Which amino acids in OmpF are suited to each aspect of its function? The structure of ciprofloxacin is shown below for reference.
Suppose you discover that bacteria that express OmpF have concentrations of <0.1uM of ciprofloxacin in the cytosol but those without this substance have concentrations of up to 50uM in the cytosol by the time they die. What does this tell you about the function of the isolated substance, OmpF, which you suspected from the start was related to quinolone resistance? How is the OmpF structure optimized for this function? Which amino acids in OmpF are suited to each aspect of its function? The structure of ciprofloxacin is shown below for reference.
OmpF porin is a type of nonspecific protein that forms the pore at the outer membrane of bacteria especially Escherichia coli. Many antibiotics such as β-lactams make use of the porin pathway to move across the outer cell membrane to reach the target cells.
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