Imagine a globular protein with a histidine that is involved in a salt bridge to an aspartic acid, in an internal (hydrophobic) region of the protein. What would happen to the pKa of that histidine R group if the protein was mutated, and the aspartic acid was replaced with an alanine? (i.e., would the pKa increase, decrease, or stay the same?). Assume that the location of the histidine stays the same. Explain your answer clearly

Q: A lysine is on the surface of a protein, near an aspartate. How does the aspartate alter the pKa of…

A: The pKa of an amino acid's side chain determines whether it is protonated (+) or deprotonated (-)…

Q: Compare and contrast cotranslational import of polypeptides with posttranslational import of…

A: Import of polypeptides across the membrane bilayer refers to the translocation process. The…

Q: Can you please help find the place value for T state?

A: Proteins are a type of macromolecule that serve a variety of roles in the cell. They assist…

Q: 1 0.8 0.6 Mutant y 0.4 Wild-Type 0.2 40 60 80 [ligand] 20

A: According to the given information, the wild type protein structure has aspartate in its primary…

Q: Which amino acid residue is preferred at which position in the following peptide for cleavage by…

A: While writing a polypeptide, the left side is the N terminus and the right side is the C terminus.

Q: Lactose permease, a protein of E. coli, is composed of a singlepolypeptide that is 417 amino acids…

A: Translation is the process by which the protein is synthesized by reading the codons in mRNA. The…

Q: Describe the general structure of a type 2 alpha helix protein. Explain how type 2 alpha helix…

A: The - (alpha) helix and the - (beta) sheet are the two most prevalent secondary structures…

Q: For each of the following sequences determine if they will most likely form an amphipathic α helix,…

A: Proteins are polymers of amino acids. The sequence of amino acids is governed by the sequences of…

Q: a) A protein gains a mutation of a surface exposed residue. The mutation is Arg --> Leu. Based on…

A: Proteins play a critical role in our body. They form enzymes, antibodies, and structural components,…

Q: The following RNA sequence represents a small messenger which can be translated in a prokaryotic…

A: The first step in translating an RNA sequence into a protein is to divide the sequence into codons,…

Q: Consider the following coding 71 nucleotide DNA template sequence (It does not contain a…

A: In cell protein formed according to the sequence on mRNA. mRNA is formed from DNA sequence by the…

Q: Consider the following in light of the concept of levels of structure (primary, secondary, tertiary,…

A: In double stranded DNA structure two strands run in anti-parallel directions through base pairing…

Q: Why would the mutation Ile -> Asp be likely to destabilize a protein? Why would the mutation Ile…

A: Mutations in proteins' amino acid sequences can have an impact on their stability. Long sequences of…

Q: Consider the following peptide sequence: Met-Ser-Val-Thr-Ile-Lys-Ala-Cys-Leu-Ser-lle-Tyr-Phe-Ser…

A: Structure of a protein or a peptide is described in four levels: primary, secondary, tertiary and…

Q: GLUT 1 contains several amphipathic transmembrane hellices, each with Its polar face oriented…

A: In the cell usually proteins are produced by the translation process and during this process usually…

Q: ead Cells have oligosaccharides displayed on their cell surface that are important for cell-cell…

A: The lipid bilayer (or phospholipid bilayer) is a thin polar membrane made of two layers of lipid…

Q: A mutation that changes an alanine to a leucine in the nucleus of a protein leads to a less active…

A: Introduction: Each organism's DNA sequence is unique. Its base-pairs sequence can change from time…

Q: Synthesis of peptide bonds is [exorgonic or endergonic]. Thus in isolation, this reaction would…

A: Protein synthesis takes place in the ribosome. It required the hydrolysis of GTP. The translation is…

Q: The following are sequences from three different alpha helices found in human proteins:…

A: The proteins are constituted of twenty naturally occurring amino acids connected via peptide…

Q: Each type of molecule listed below is recognized by a specific class of nuclear import receptor…

A: Importin and exportin refer to the nuclear transport receptors that are responsible for the…

Q: Ribosomal proteins have high pI values. Why is this advantageous for ribosome stability?

A: Ribosome is the complex of rRNA and proteins present in the cytoplasm of a cell. It is responsible…

Q: Cystic fibrosis (CF) is an inherited disorder caused by different types of mutations, many of which…

A: CF is caused by a mutation in a gene called the cystic fibrosis transmembrane conductance regulator…

Q: HbS results from the substitution of valine forglutamic acid at the number 6 position in the b…

A: HbS is the result of a single base-pair mutation in the gene responsible for the beta-globin chain…

Q: The PAM1 matrix penalizes mismatching amino acids more than higher numbered PAM matrices. Explain…

A: PAM (POINT ACCEPTED MATRIX) indicates the probability of a mutation of an amino acid in a given…

Q: A lysine is burined inside a protein surrounded by hydrophobic resiudes, how does this affect the…

A: Answer :- The behavior of amino acid residues within a protein is profoundly influenced by their…

Q: In the protein adenylate kinase, the C-terminal region has the sequence Val-Asp-Asp-Val-Phe-…

A: A helical wheel representation is a type of plot or visual representation used to illustrate the…

Q: Erk and P-Erk live in two different locations within the cell even though they are just two…

A: * Mitogen activated protein kinase also called as  MAPK and  p42MAPK, and ERK2 * It is an enzyme…

Q: What amino acid would a tRNA with anticodon CUA carry? Enter the 3 letter code only [A]. [e.g. Met…

A: tRNA stands for the transfer RNA and it has L- shaped structure . Transfer RNA acts as an adopter…

Osmosis

In simple words, osmosis is the slow, gradual movement of a liquid through a membrane. But there are nuances to this process. For instance, there has to be an imbalance in the distribution of solute in the liquid on either side of the membrane, which has to be semipermeable. The liquid in the region with a lower solute concentration moves to the region with a higher concentration, thereby displacing the solution in the process. The objective is to equalize the concentration of molecules on both sides of the membrane; the displacement of liquid can be viewed as a byproduct of this equalization. Since there is no energy required to carry osmosis, it is considered a passive process.