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The S3’ pocket on PfSUB1 (attached) contains the side chains of Lys465 and Tyr427. Researchers discovered that the Km for substrates with acidic residues in the P3’ position are much lower than those with nonpolar resides at the P3’ position in PfSUB1. Explain the Km data.

The S3’ pocket on PfSUB1 (attached) contains the side chains of Lys465 and Tyr427. Researchers discovered that the Km for substrates with acidic residues in the P3’ position are much lower than those with nonpolar resides at the P3’ position in PfSUB1. Explain the Km data.

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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The S3’ pocket on PfSUB1 (attached) contains the side chains of Lys465 and Tyr427. Researchers discovered that the Km for substrates with acidic residues in the P3’ position are much lower than those with nonpolar resides at the P3’ position in PfSUB1. Explain the Km data.

The image displays a molecular structure diagram of a peptide chain with specific labeling for each amino acid or peptide residue. The structure includes the following labels and features: - **P5:** Represents the C-terminal end of a peptide segment containing an amide group. - **P4:** A hydrophobic side chain with a potential isopropyl group. - **P3:** Contains a hydroxyl group attached to the central carbon, indicating a polar side chain. - **P2:** A non-polar side chain likely containing a hydrocarbon chain. - **P1:** Features a functional group suggesting a negatively charged carboxylate ion. - **P1':** An amino acid with an amino group and possibly a central carbon forming part of the backbone. - **P2':** Displays a side chain that may have another hydrocarbon feature. - **P3':** Consists of a backbone carbonyl and perhaps a polar or charged side group. - **P4':** Non-polar side chain with alkyl features, continuing the peptide backbone. - **P5':** Contains a terminal carboxyl group, marking this structure as a C-terminal or potentially a free acid form. Overall, the diagram provides a detailed look at the primary structure of a peptide, illustrating the sequence and composition of its amino acid residues with specific labeling of each position.
Transcribed Image Text:The image displays a molecular structure diagram of a peptide chain with specific labeling for each amino acid or peptide residue. The structure includes the following labels and features: - **P5:** Represents the C-terminal end of a peptide segment containing an amide group. - **P4:** A hydrophobic side chain with a potential isopropyl group. - **P3:** Contains a hydroxyl group attached to the central carbon, indicating a polar side chain. - **P2:** A non-polar side chain likely containing a hydrocarbon chain. - **P1:** Features a functional group suggesting a negatively charged carboxylate ion. - **P1':** An amino acid with an amino group and possibly a central carbon forming part of the backbone. - **P2':** Displays a side chain that may have another hydrocarbon feature. - **P3':** Consists of a backbone carbonyl and perhaps a polar or charged side group. - **P4':** Non-polar side chain with alkyl features, continuing the peptide backbone. - **P5':** Contains a terminal carboxyl group, marking this structure as a C-terminal or potentially a free acid form. Overall, the diagram provides a detailed look at the primary structure of a peptide, illustrating the sequence and composition of its amino acid residues with specific labeling of each position.
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