vessel wall. Which of the following situations would lead to relaxation of the smooth muscle cells in the absence of acetylcholine? arginine swer: activated nerve terminal -acetylcholine NO endothelial cell RAPID DIFFUSION OF NO ACROSS MEMBRANES NO bound to guanylyl cyclase GTP cyclic GMP RAPID RELAXATION OF SMOOTH MUSCLE CELL smooth muscle cell A) A smooth muscle cell that has a defect in guanylyl cyclase such that it cannot bind NO B) A muscle cell that has a defect in guar ase such that it constitutively converts GTP to cyclic GMP C) A muscle cell that has cyclic GMP phosphodiesterase constitutively active D) A drug that blocks an enzyme involved in the metabolic pathway from arginine to NO E) None of the above Explanation:

Human Anatomy & Physiology (11th Edition)
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Chapter1: The Human Body: An Orientation
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20. The figure below shows the pathway through which nitric oxide (NO) triggers smooth muscle relaxation in a blood-
vessel wall. Which of the following situations would lead to relaxation of the smooth muscle cells in the absence of
acetylcholine?
arginine
Answer:
activated.
nerve terminal
-acetylcholine
NO
endothelial cell
RAPID DIFFUSION OF NO
ACROSS MEMBRANES
NO bound to
guanylyl cyclase
GTP
cyclic
GMP
RAPID RELAXATION
OF SMOOTH MUSCLE CELL
smooth muscle cell
A) A smooth muscle cell that has a defect in guanylyl cyclase such that it cannot bind NO
B) A muscle cell that has a defect in guanylyl cyclase such that it constitutively converts GTP to cyclic GMP
C) A muscle cell that has cyclic GMP phosphodiesterase constitutively active
D) A drug that blocks an enzyme involved in the metabolic pathway from arginine to NO
E) None of the above
Explanation:
Transcribed Image Text:20. The figure below shows the pathway through which nitric oxide (NO) triggers smooth muscle relaxation in a blood- vessel wall. Which of the following situations would lead to relaxation of the smooth muscle cells in the absence of acetylcholine? arginine Answer: activated. nerve terminal -acetylcholine NO endothelial cell RAPID DIFFUSION OF NO ACROSS MEMBRANES NO bound to guanylyl cyclase GTP cyclic GMP RAPID RELAXATION OF SMOOTH MUSCLE CELL smooth muscle cell A) A smooth muscle cell that has a defect in guanylyl cyclase such that it cannot bind NO B) A muscle cell that has a defect in guanylyl cyclase such that it constitutively converts GTP to cyclic GMP C) A muscle cell that has cyclic GMP phosphodiesterase constitutively active D) A drug that blocks an enzyme involved in the metabolic pathway from arginine to NO E) None of the above Explanation:
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