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1 Unoccupied receptor does not interact with G, protein. Extra- collular space -Hormone or neuro- transmitter Cell membrane Gs protein with bound GDP Synaptic signaling Receptor Target cell Inactive adenylyl Cytosol GOP cyclase Nerve cell Occupied receptor changes 2 shape and interacts with a subunit of G, protein. G, protein releases GDP and binds GTP. Neurotransmitter Endocrine signaling Hormone Inactive adenylyl cyclase GTP Target cell GDP a Subunit of G, protein 3 dissociates from By and Blood vessel activates adenylyl cyclase. Active adenylyl cyclase Direct contact АТР Gap junction GTP CAMP + PP When hormone is no longer 4 present, the receptor reverts to resting state. GTP on the a subunít is hydrolyzed to GDP, a rejoins By, and adenylyl cyclase is deactivated. Signaling cell Target cells Inactive adenylyl cyclase ACTIVITY 10.3 Kindly refer to Model 10.3 and answer the following 1. Why is there a need to regulate the metabolic activity of the cells? 2. What are the two main mechanisms by which cell signaling is regulated? What the difference between the two? 3. Why is it that the secondary messenger system is named as such? What is the two most common secondary messenger system on energy metabolism? 4. Explain the mechanism of action of the adenyl cyclic system using a schematic diagram. 5. Cite a metabolic pathway where active protein kinase is needed and explain its mechanism of action 214 Copyright 2019. All Rights Reserved.

1 Unoccupied receptor does not interact with G, protein. Extra- collular space -Hormone or neuro- transmitter Cell membrane Gs protein with bound GDP Synaptic signaling Receptor Target cell Inactive adenylyl Cytosol GOP cyclase Nerve cell Occupied receptor changes 2 shape and interacts with a subunit of G, protein. G, protein releases GDP and binds GTP. Neurotransmitter Endocrine signaling Hormone Inactive adenylyl cyclase GTP Target cell GDP a Subunit of G, protein 3 dissociates from By and Blood vessel activates adenylyl cyclase. Active adenylyl cyclase Direct contact АТР Gap junction GTP CAMP + PP When hormone is no longer 4 present, the receptor reverts to resting state. GTP on the a subunít is hydrolyzed to GDP, a rejoins By, and adenylyl cyclase is deactivated. Signaling cell Target cells Inactive adenylyl cyclase ACTIVITY 10.3 Kindly refer to Model 10.3 and answer the following 1. Why is there a need to regulate the metabolic activity of the cells? 2. What are the two main mechanisms by which cell signaling is regulated? What the difference between the two? 3. Why is it that the secondary messenger system is named as such? What is the two most common secondary messenger system on energy metabolism? 4. Explain the mechanism of action of the adenyl cyclic system using a schematic diagram. 5. Cite a metabolic pathway where active protein kinase is needed and explain its mechanism of action 214 Copyright 2019. All Rights Reserved.

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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1 Unoccupied receptor does not interact with G, protein. Extra- collular space -Hormone or neuro- transmitter Cell membrane Gs protein with bound GDP Synaptic signaling Receptor Target cell Inactive adenylyl Cytosol GOP cyclase Nerve cell Occupied receptor changes 2 shape and interacts with a subunit of G, protein. G, protein releases GDP and binds GTP. Neurotransmitter Endocrine signaling Hormone Inactive adenylyl cyclase GTP Target cell GDP a Subunit of G, protein 3 dissociates from By and Blood vessel activates adenylyl cyclase. Active adenylyl cyclase Direct contact АТР Gap junction GTP CAMP + PP When hormone is no longer 4 present, the receptor reverts to resting state. GTP on the a subunít is hydrolyzed to GDP, a rejoins By, and adenylyl cyclase is deactivated. Signaling cell Target cells Inactive adenylyl cyclase
Transcribed Image Text:1 Unoccupied receptor does not interact with G, protein. Extra- collular space -Hormone or neuro- transmitter Cell membrane Gs protein with bound GDP Synaptic signaling Receptor Target cell Inactive adenylyl Cytosol GOP cyclase Nerve cell Occupied receptor changes 2 shape and interacts with a subunit of G, protein. G, protein releases GDP and binds GTP. Neurotransmitter Endocrine signaling Hormone Inactive adenylyl cyclase GTP Target cell GDP a Subunit of G, protein 3 dissociates from By and Blood vessel activates adenylyl cyclase. Active adenylyl cyclase Direct contact АТР Gap junction GTP CAMP + PP When hormone is no longer 4 present, the receptor reverts to resting state. GTP on the a subunít is hydrolyzed to GDP, a rejoins By, and adenylyl cyclase is deactivated. Signaling cell Target cells Inactive adenylyl cyclase
ACTIVITY 10.3 Kindly refer to Model 10.3 and answer the following 1. Why is there a need to regulate the metabolic activity of the cells? 2. What are the two main mechanisms by which cell signaling is regulated? What the difference between the two? 3. Why is it that the secondary messenger system is named as such? What is the two most common secondary messenger system on energy metabolism? 4. Explain the mechanism of action of the adenyl cyclic system using a schematic diagram. 5. Cite a metabolic pathway where active protein kinase is needed and explain its mechanism of action 214 Copyright 2019. All Rights Reserved.
Transcribed Image Text:ACTIVITY 10.3 Kindly refer to Model 10.3 and answer the following 1. Why is there a need to regulate the metabolic activity of the cells? 2. What are the two main mechanisms by which cell signaling is regulated? What the difference between the two? 3. Why is it that the secondary messenger system is named as such? What is the two most common secondary messenger system on energy metabolism? 4. Explain the mechanism of action of the adenyl cyclic system using a schematic diagram. 5. Cite a metabolic pathway where active protein kinase is needed and explain its mechanism of action 214 Copyright 2019. All Rights Reserved.
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