To maximize the activity of an α4β2 nicotinic Achtylchcholine Receptor (nAChR), how many agonist binding sitea should be occupied?
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Dear Expert.
Thank you for your advice, which is good and helpful. I note that your answer is "when 3 binding sites have been occupied the activity of these receptors is maximum."
However, I also note that for a similar question (see below) on α7 nicotinic Acetylcholine Receptor (nAChR) also gives the same answer, ie. at least 3 agonist binding sites should be occupied.
Another Question - "To maximize the activity of an α7 nAChR, how many agonist binding sites should be occupied."
I understand that in α7 nAChR, binding to two sites is more effective and binding to three sites is most effective for activation. On the other hand, binding to four or five sites in the nAChRs of chromosome 7 speeds up desensitization more than activation.
Therefore, to maximize the activity of an α7 nicotinic Acetylcholine Receptor (nAChR) is also "3 sites".
Am I right?
by Bartleby Expert
