Triose phosphate isomerase In a key reaction of glycolysis, dihydroxyacetone phosphate (DHAP) is isomerized into glyceraldehyde 3-phosphate (G3P) by the action of the enzyme triose phosphate isomerase: CH₂OH C=0 CH₂OPO,²- DHAP CHO HC-OH CH₂OPO₂²¹ G3P AG" = +7.5 kJ/mol Because AG is positive, the equilibrium lies to the left. (a) Calculate the equilibrium constant for this reaction, assuming a temperature of 37 °C. (b) In the cell, depletion of G3P makes the reaction proceed. What is the value of AG if the concentration of G3P is kept at 1/100 of the value of the concentration of DHAP?
Triose phosphate isomerase In a key reaction of glycolysis, dihydroxyacetone phosphate (DHAP) is isomerized into glyceraldehyde 3-phosphate (G3P) by the action of the enzyme triose phosphate isomerase: CH₂OH C=0 CH₂OPO,²- DHAP CHO HC-OH CH₂OPO₂²¹ G3P AG" = +7.5 kJ/mol Because AG is positive, the equilibrium lies to the left. (a) Calculate the equilibrium constant for this reaction, assuming a temperature of 37 °C. (b) In the cell, depletion of G3P makes the reaction proceed. What is the value of AG if the concentration of G3P is kept at 1/100 of the value of the concentration of DHAP?
Biochemistry
6th Edition
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Reginald H. Garrett, Charles M. Grisham
Chapter20: Electron Transport And Oxidative Phosphorylation
Section: Chapter Questions
Problem 2P
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![Triose phosphate isomerase
In a key reaction of glycolysis, dihydroxyacetone phosphate (DHAP) is isomerized into
glyceraldehyde 3-phosphate (G3P) by the action of the enzyme triose phosphate isomerase:
CH₂OH
C=O
CH₂OPO3²-
DHAP
CHO
HC-OH
CH₂OPO3²-
G3P
AG°¹ +7.5 kJ/mol
Because AG is positive, the equilibrium lies to the left.
(a) Calculate the equilibrium constant for this reaction, assuming a temperature of 37 °C.
(b) In the cell, depletion of G3P makes the reaction proceed. What is the value of AG if the
concentration of G3P is kept at 1/100 of the value of the concentration of DHAP?
C
ZOOM
+](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2Ff99f627c-fb30-4eda-a4b4-43a4443b7001%2Faff9f1c0-c93e-468f-b4f2-4881ae4785db%2Fakel29g_processed.png&w=3840&q=75)
Transcribed Image Text:Triose phosphate isomerase
In a key reaction of glycolysis, dihydroxyacetone phosphate (DHAP) is isomerized into
glyceraldehyde 3-phosphate (G3P) by the action of the enzyme triose phosphate isomerase:
CH₂OH
C=O
CH₂OPO3²-
DHAP
CHO
HC-OH
CH₂OPO3²-
G3P
AG°¹ +7.5 kJ/mol
Because AG is positive, the equilibrium lies to the left.
(a) Calculate the equilibrium constant for this reaction, assuming a temperature of 37 °C.
(b) In the cell, depletion of G3P makes the reaction proceed. What is the value of AG if the
concentration of G3P is kept at 1/100 of the value of the concentration of DHAP?
C
ZOOM
+
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