The glycolytic enzyme aldolase catalyzes the following cleavage reaction: Fructose 1,6-bisphosphate ↔ glyceraldehyde-3-phosphate + dihydroxyacetone phosphate Here is information on the concentrations of these compounds in hepatocytes (liver cells). Reactant Concentration (M) Fructose 1,6-bisphosphate 1.4 x 10-5 glyceraldehyde-3-phosphate 3 x 10-6 dihydroxyacetone phosphate 1.6 x 10-5 The standard transformed free energy change (ΔG'°) of the reaction is +23.8 kJ/mol. At body temperature (37oC), is the reaction exergonic or endergonic in the hepatocyte? What is the value of the actual free energy change (ΔG) in the cell?
The glycolytic enzyme aldolase catalyzes the following cleavage reaction:
Fructose 1,6-bisphosphate ↔ glyceraldehyde-3-phosphate + dihydroxyacetone phosphate
Here is information on the concentrations of these compounds in hepatocytes (liver cells).
| Reactant | Concentration (M) |
| Fructose 1,6-bisphosphate | 1.4 x 10-5 |
| glyceraldehyde-3-phosphate | 3 x 10-6 |
| dihydroxyacetone phosphate | 1.6 x 10-5 |
The standard transformed free energy change (ΔG'°) of the reaction is +23.8 kJ/mol.
At body temperature (37oC), is the reaction exergonic or endergonic in the hepatocyte? What is the value of the actual free energy change (ΔG) in the cell?
Aldolase is an enzyme that catalyses one of the reaction of glycolytic pathway by performing a cleavage reaction. It is a reversible reaction.
Change in free energy occurs in a reaction due to formation, breakage and isomerization of the bonds during reaction. It can be be calculated by the equation given below-
ΔG=ΔGo +RT lnQ
Here,
ΔG= Change in energy
Q= [Concentration of Product/ Concentration of Reactant]
R= Gas Constant (8.314 JK-1mol-1).
Go = Gibbs Free energy
T= Temperature in kelvin Scale
Trending now
This is a popular solution!
Step by step
Solved in 3 steps
