The sigma-70 promoter is very well-studied. The Sigma-54 promoter, on the other hand, hasn't had quite as much study devoted to it, but a consensus sequence for Sigma-54 promoters has been determined, and it looks like this: C FIGCCACATCCT AGGG 5-26-25-24-23-22 -21 -20 -19 -18 -17 -16-15-14-13-12-11 -10 3 wablogo.berkalay.edu

Human Anatomy & Physiology (11th Edition)
11th Edition
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Author:Elaine N. Marieb, Katja N. Hoehn
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Chapter1: The Human Body: An Orientation
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The sigma-70 promoter is very well-studied. The Sigma-54 promoter, on the other hand, hasn't had
quite as much study devoted to it, but a consensus sequence for Sigma-54 promoters has been
determined, and it looks like this:
C
GAAA
FICGCACTECT
УА
C
5-26-25-24 -23 -22 -21 -20 -19 -18 -17 -16-15-14-13-12-11 -10 3
wablogo berkalay.edu
(From Franke et. Al, 2011 BMC Genomics)
If you were studying a gene with a promoter that exactly matched the consensus sequence, which
base would, if mutated, probably make the largest difference in the ability of Sigma-54 to bind to a
promoter?
O Base position 26
Base position 10
Base position 12
Base position 16
Transcribed Image Text:The sigma-70 promoter is very well-studied. The Sigma-54 promoter, on the other hand, hasn't had quite as much study devoted to it, but a consensus sequence for Sigma-54 promoters has been determined, and it looks like this: C GAAA FICGCACTECT УА C 5-26-25-24 -23 -22 -21 -20 -19 -18 -17 -16-15-14-13-12-11 -10 3 wablogo berkalay.edu (From Franke et. Al, 2011 BMC Genomics) If you were studying a gene with a promoter that exactly matched the consensus sequence, which base would, if mutated, probably make the largest difference in the ability of Sigma-54 to bind to a promoter? O Base position 26 Base position 10 Base position 12 Base position 16
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