The researchers claim that treatment with a compound that inhibits dephosphorylation of the intracellular domain of the Brec protein will inhibit expression of A in Brec-WT cells but not in Brec-MUT cells. Based on the information provided, provide reasoning to refute their claim. Question 1Solid tumors are clusters of cancer cells and often contain blood vessels. When molecule Bbinds to the wild-type Brec protein in the plasma membrane of certain solid tumor cancer cells(Figure 1), the cancer cells express the membrane protein A and sometimes stimulate increasedgrowth of blood vessels into the tumors.Cells with a particular mutation in the Brec gene (Brec-MUT cells) have much increasedexpression levels of A and stimulate greater growth of blood vessels than do cancer cells withthe wild-type Brec (Brec-WT cells); the cells with the mutant Brec can trigger intracellularsignaling in the absence of B.Researchers proposed that the signaling pathway modeled in Figure 1 is triggered by activationof the wild-type Brec and is associated with phosphorylation and activation of kinase D,expression of A, and the ability of the cancer cells to stimulate blood vessel growth.Brec(Active)D (Inactive)C-PB℗-D (Active)Kinase(Inactive)Brec (Inactive)P-Kinase(Active)Plasma MembraneAStimulategrowth ofblood vesselsinto tumorsP Phosphate group

Name: The researchers claim that treatment with a compound that inhibits dep
Uploaded: 2024-03-20T06:42:41.000Z
Channel: Bartleby
Description: The researchers claim that treatment with a compound that inhibits dephosphorylation of the intracellular domain of the Brec protein will inhibit expression of A in Brec-WT cells but not in Brec-MUT cells. Based on the information provided, provide r