The ratio of nonsynonymous differences pernonsynonymous site, dN, to synonymous differences per synonymous site, dS, can be usedto test for positive selection Imagine that in a duplicate pair of loci, oneparalog is evolving neutrally while the other isevolving under strong positive selection. Whatspecific data are needed to detect that situationusing the dN/dS ratio, and what pattern do youexpect to see?
Genetic Variation
Genetic variation refers to the variation in the genome sequences between individual organisms of a species. Individual differences or population differences can both be referred to as genetic variations. It is primarily caused by mutation, but other factors such as genetic drift and sexual reproduction also play a major role.
Quantitative Genetics
Quantitative genetics is the part of genetics that deals with the continuous trait, where the expression of various genes influences the phenotypes. Thus genes are expressed together to produce a trait with continuous variability. This is unlike the classical traits or qualitative traits, where each trait is controlled by the expression of a single or very few genes to produce a discontinuous variation.
The ratio of nonsynonymous differences per
nonsynonymous site, dN, to synonymous differences per synonymous site, dS, can be used
to test for positive selection
Imagine that in a duplicate pair of loci, one
paralog is evolving neutrally while the other is
evolving under strong positive selection. What
specific data are needed to detect that situation
using the dN/dS ratio, and what pattern do you
expect to see?
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