In the Human Genome Project, researchers have collectedlinkage data from many crosses in which the male washeterozygous for molecular markers and many crosses wherethe female was heterozygous for the markers. The distancebetween the same two markers, computed in map units, isdifferent between males and females. In other words, thelinkage maps for human males and females are not the same.Propose an explanation for this discrepancy. Do you think thesizes of chromosomes (excluding the Y chromosome) in humanmales and females are different? How could physical mappingresolve this discrepancy?

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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In the Human Genome Project, researchers have collected
linkage data from many crosses in which the male was
heterozygous for molecular markers and many crosses where
the female was heterozygous for the markers. The distance
between the same two markers, computed in map units, is
different between males and females. In other words, the
linkage maps for human males and females are not the same.
Propose an explanation for this discrepancy. Do you think the
sizes of chromosomes (excluding the Y chromosome) in human
males and females are different? How could physical mapping
resolve this discrepancy?

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