In the early 1970s, Igor Dawid and Antonie Blacklerconducted classical experiments that first showed directly the maternal inheritance of mtDNA in vertebrates.Their studies used crosses between two closely relatedspecies of frogs, Xenopus laevis and Xenopus borealis,which have mtDNAs that vary in many nucleotides. Thetechniques they used at the time were not sensitiveenough to detect small amounts of paternal DNA. Whattechniques that are highly sensitive to small amounts ofDNA could be used today? How could you use thesetechniques to determine if paternal mitochondrial DNAwas present in the progeny of the interspecies cross?

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Mitochondrial Mutations

A mitochondrion is a cellular organelle that serves as the site for cellular respiration and energy production (ATP or Adenosine Triphosphate). It is a double-membrane-bound organelle and is only present in eukaryotic cells.