his research exploited the principles of Mendelian genetics combined with the MCR technique to genetically manipulate fruit flies. Now, suppose you do a similar experiment. You perform two crosses: one that allows for Mendelian patterns of inheritance, and another that uses MCR with CRISPR-Cas9 to genetically edit the eye color of fruit flies. In fruit flies, the gene for eye color is located on the X chromosome. Red eyes (wild type, w+) are dominant to white eyes (mutant, w-). Let’s see how well you can predict genotype and phenotype ratios resulting from the two crosses. Genetic cross 1 (without MCR): Cross between a white-eyed male and a homozygous red-eyed female. Genetic cross 2 (with MCR): Cross between an MCR-element (carries the CRISPR-Cas9 construct) white-eyed male and a homozygous red-eyed female. Keep in mind, this technology converts a heterozygous genotype to a homozygous recessive genotype. Drag the labels to the table to fill in the genotypic and phenotypic ratios.
This research exploited the principles of
You perform two crosses: one that allows for Mendelian patterns of inheritance, and another that uses MCR with CRISPR-Cas9 to genetically edit the eye color of fruit flies. In fruit flies, the gene for eye color is located on the X chromosome. Red eyes (wild type, w+) are dominant to white eyes (mutant, w-). Let’s see how well you can predict genotype and
Genetic cross 1 (without MCR): Cross between a white-eyed male and a homozygous red-eyed female.
Genetic cross 2 (with MCR): Cross between an MCR-element (carries the CRISPR-Cas9 construct) white-eyed male and a homozygous red-eyed female. Keep in mind, this technology converts a heterozygous genotype to a homozygous recessive genotype.
Drag the labels to the table to fill in the genotypic and phenotypic ratios.
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