Genetic linkage between alleles can modify how natural selection affects the frequencies of neutral, deleterious, and beneficial alleles. In the follow scenarios, you will consider the fates of alleles at two loci (A and B) under different amounts of genetic linkage. Write 1-2 sentences explaining what you expect to happen under the following scenarios, and why you expect it. A. Assume that there are two neutral alleles at the B locus (B and b). A beneficial mutation arises in the A locus (A) on a haplotype where it is linked to the ballele. Assuming tight genetic linkage between A' and b (c≈ 0), what do you expect to happen to the frequency of the ballele and why? B. Assume there is a deleterious allele at the B locus (b) and a beneficial allele (B). A beneficial mutation arises in the A locus (A) on a haplotype where it is linked to the b allele. The benefit of the A' allele is greater than the deleterious effect of the b allele, and there is tight genetic linkage between A' and b (c≈ 0). What do you expect to happen to the frequency of the ballele and why? C. Assume there is a deleterious allele at the B locus (b) and a beneficial allele (B). A beneficial mutation arises in the A locus (A) on a haplotype where it is linked to the b allele. The benefit of the A' allele is greater than the deleterious effect of the b allele, and there is substantial recombination between A' and b (c> 0). What do you expect to happen to the frequency of the ballele and why? D. Assume there is a deleterious allele at the B locus (b) and a beneficial allele (B). A deleterious mutation arises in the A locus (A") on a haplotype where it is linked to the B allele. The cost of the A" allele is less than the beneficial effect of the B allele, and there is tight genetic linkage between A and B (c≈ 0). What do you expect to happen to the frequency of the A and B alleles and why?

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Genetic linkage between alleles can modify how natural selection affects the frequencies of
neutral, deleterious, and beneficial alleles. In the follow scenarios, you will consider the
fates of alleles at two loci (A and B) under different amounts of genetic linkage. Write 1-2
sentences explaining what you expect to happen under the following scenarios, and why
you expect it.
A. Assume that there are two neutral alleles at the B locus (B and b). A beneficial
mutation arises in the A locus (A) on a haplotype where it is linked to the ballele.
Assuming tight genetic linkage between A' and b (c≈ 0), what do you expect to
happen to the frequency of the ballele and why?
B. Assume there is a deleterious allele at the B locus (b) and a beneficial allele (B). A
beneficial mutation arises in the A locus (A) on a haplotype where it is linked to the
b allele. The benefit of the A' allele is greater than the deleterious effect of the b
allele, and there is tight genetic linkage between A' and b (c≈ 0). What do you
expect to happen to the frequency of the ballele and why?
C. Assume there is a deleterious allele at the B locus (b) and a beneficial allele (B). A
beneficial mutation arises in the A locus (A) on a haplotype where it is linked to the
b allele. The benefit of the A' allele is greater than the deleterious effect of the b
allele, and there is substantial recombination between A' and b (c > 0). What do
you expect to happen to the frequency of the b allele and why?
D. Assume there is a deleterious allele at the B locus (b) and a beneficial allele (B). A
deleterious mutation arises in the A locus (A") on a haplotype where it is linked to
the B allele. The cost of the A" allele is less than the beneficial effect of the B allele,
and there is tight genetic linkage between A" and B (c≈ 0). What do you expect to
happen to the frequency of the A" and B alleles and why?
Transcribed Image Text:Genetic linkage between alleles can modify how natural selection affects the frequencies of neutral, deleterious, and beneficial alleles. In the follow scenarios, you will consider the fates of alleles at two loci (A and B) under different amounts of genetic linkage. Write 1-2 sentences explaining what you expect to happen under the following scenarios, and why you expect it. A. Assume that there are two neutral alleles at the B locus (B and b). A beneficial mutation arises in the A locus (A) on a haplotype where it is linked to the ballele. Assuming tight genetic linkage between A' and b (c≈ 0), what do you expect to happen to the frequency of the ballele and why? B. Assume there is a deleterious allele at the B locus (b) and a beneficial allele (B). A beneficial mutation arises in the A locus (A) on a haplotype where it is linked to the b allele. The benefit of the A' allele is greater than the deleterious effect of the b allele, and there is tight genetic linkage between A' and b (c≈ 0). What do you expect to happen to the frequency of the ballele and why? C. Assume there is a deleterious allele at the B locus (b) and a beneficial allele (B). A beneficial mutation arises in the A locus (A) on a haplotype where it is linked to the b allele. The benefit of the A' allele is greater than the deleterious effect of the b allele, and there is substantial recombination between A' and b (c > 0). What do you expect to happen to the frequency of the b allele and why? D. Assume there is a deleterious allele at the B locus (b) and a beneficial allele (B). A deleterious mutation arises in the A locus (A") on a haplotype where it is linked to the B allele. The cost of the A" allele is less than the beneficial effect of the B allele, and there is tight genetic linkage between A" and B (c≈ 0). What do you expect to happen to the frequency of the A" and B alleles and why?
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