The data below show the inhibition of rat liver alcohol dehydrogenase (ADH) by tetramethylene sulfoxide, a drug that is used to treat methanol poisoning. What form of ADH does tetramethylene sulfoxide bind to? 8 A [1] = 0.6 mM 0.4 mM 0.2 mM 0.5 1.0 1.5 2.0 2.5 1/(ethanol), mM -1 O Only to the free enzyme, E. O Only to the enzyme-substrate complex, ES. O To both E and ES, but with higher affinity for E. O To a serine residue at the enzyme active site. O To both E and ES, with equal affinity.
The data below show the inhibition of rat liver alcohol dehydrogenase (ADH) by tetramethylene sulfoxide, a drug that is used to treat methanol poisoning. What form of ADH does tetramethylene sulfoxide bind to? 8 A [1] = 0.6 mM 0.4 mM 0.2 mM 0.5 1.0 1.5 2.0 2.5 1/(ethanol), mM -1 O Only to the free enzyme, E. O Only to the enzyme-substrate complex, ES. O To both E and ES, but with higher affinity for E. O To a serine residue at the enzyme active site. O To both E and ES, with equal affinity.
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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