The antibiotic valinomycin is an ionophore that forms a specific complex with potassium ion. Because the complex is lipophilic and can diffuse into the membrane, valinomycin brings about the transport of K+ through the inner membrane. Valinomycin acts by decreasing the ∆ψ (membrane potential) component of the pmf, without a direct effect on the pH gradient. Another antibiotic, nigericin, acts as a K+ >H+ antiporter; itcarries H+ in one direction, coupled with the reverse transport of K+. Thus,nigericin dissipates the pH component of the pmf, with little effect on ∆c.Which antibiotic, nigericin or valinomycin, do you predict would have thegreater effect on oxidative phosphorylation when administered to respiring mitochondria? Assume the antibiotics are added to a suspension of mitochondria in equimolar amounts. Briefly explain your reasoning.

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Cell Signaling

It allows cells to perform various cellular activities, coordinate, and interact with other cells. All cells of an organism receive signals from their environments and respond accordingly. Even the unicellular eukaryotes receive signals secreted by other cells and respond. In the case of yeast, mating takes place by signaling between the yeast cells. Communication by cell signaling in a multicellular organism has become a vast and important part of various fields of biology.