Liver cells are in contact with the blood and exchange a variety of substances with the blood plasma (the noncellular part of blood). The concentration of water is equal in the cytoplasm of liver cells and in the blood plasma.  Explain this observation in terms of membrane permeability and transport mechanisms. Animal cells typically maintain a higher concentration of Na+ outside the cell and a higher concentration of K+ inside the cell via the Na+-K+ pump. The drug ouabain inhibits the activity of the Na+-K+ pump.  A nerve cell is incubated in ouabain.  Predict what will happen to the concentrations of Na+ and K+ inside and outside the nerve cell as a result.

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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  1. Liver cells are in contact with the blood and exchange a variety of substances with the blood plasma (the noncellular part of blood). The concentration of water is equal in the cytoplasm of liver cells and in the blood plasma.  Explain this observation in terms of membrane permeability and transport mechanisms.
  2. Animal cells typically maintain a higher concentration of Na+ outside the cell and a higher concentration of K+ inside the cell via the Na+-K+ pump. The drug ouabain inhibits the activity of the Na+-K+ pump.  A nerve cell is incubated in ouabain.  Predict what will happen to the concentrations of Na+ and K+ inside and outside the nerve cell as a result.
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Plasma membrane is not permeable to all molecules. charge molecules are not permeable to plasma membrane that is why it need pump or transporters to transport large and charge molecule.

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