There are differences in Na+, K+, and Cl- ion concentrations across the membrane. Knowing that ions like to flow down their respective concentration gradients explain how the movement of Cl- and K+ ions can result in membrane hyperpolarization.
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There are differences in Na+, K+, and Cl- ion concentrations across the membrane. Knowing that ions like to flow down their respective concentration gradients explain how the movement of Cl- and K+ ions can result in membrane hyperpolarization.
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Neurons are known to generate electrical signals when the permeability of the cell membrane is altered in response to particular ions. They include Na+, K+, Cl- etc. The potential difference so measured in most resting neurons ranges from 30 to 90 mV with the inside of the cell being more negative than the outside. The membrane is said to be polarized when there occurs a difference in the membrane potential.
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- Assume that a membrane permeable to Na+ but not to Cl- separates two solutions. The concentration of sodium chloride on side 1 is higher than on side 2. Which of the following ionic movements would occur? a. Na+ would move until its concentration gradient is dissipated (until the concentration of Na+ on side 2 is the same as the concentration of Na+ on side 1). b. Cl- would move down its concentration gradient from side 1 to side 2. c. A membrane potential, negative on side 1, would develop. d. A membrane potential, positive on side 1, would develop. e. None of the preceding is correct.One of the important uses of the Nernst equation is in describing the flow of ions across plasma membranes. Ions move under the influence of two forces: the concentration gradient (given in electrical units by the Nernst equation) and the electrical gradient (given by the membrane voltage). This is summarized by Ohms law: Ix=Gx(VmEx) which describes the movement of ion x across the membrane. I is the current in amperes (A); G is the conductance, a measure of the permeability of x, in Siemens (S), which is I/V;Vm is the membrane voltage; and Ex is the equilibrium potential of ion x. Not only does this equation tell how large the current is, but it also tells what direction the current is flowing. By convention, a negative value of the current represents either a positive ion entering the cell or a negative ion leaving the cell. The opposite is true of a positive value of the current. a. Using the following information, calculate the magnitude of Na [ Na+ ]0=145mM,[ Na+ ]i=15mM,Gna+=1nS,Vm=70mV b. Is Na+ entering or leaving the cell? c. Is Na+ moving with or against the concentration gradient? Is it moving with or against the electrical gradient?if an object b has a plasma sodium concentration of 135mOsm/L and an intracellular concentration of 4mOsm/L. It also has a plasma concentration of potassium of 20mOsm/L and an intracellular concentration of 200mOsm/L. studies identify that the cells have a permeability to potassium that is 10 times greater than sodium. What is the resting membrane potential
- Explain the contribution of the Na+/K+ pump activity to the genesis and maintenance of the resting membrane potential and indicate which category of membrane transport the Na+/K+ pump belongs toThe extracellular concentration of Cl-Cl¯ is 123 mM and the intracellular concentration is 4 mM. In which direction does Cl-CI¯| flow through an open channel when the membrane potential is in the -60 mV-60 mV to +30 mV+30 mV range?If sodium permeability were to increase compared to normal what would be the resulting effect on the membrane potential 1.The charge on the inside of the cell becomes less negative compared to resting conditions and hyperpolarizes 2.The charge on the inside of the cell becomes more negative compared to resting conditions and hyperpolarizes 3.The charge on the inside of the cell becomes less negative compared to resting conditions and depolarizes 4.The charge on the inside of the cell becomes more negative compared to resting conditions and depolarizes
- Chloride ions (Cl-) behave a bit differently to Na+ and K+ in that most cells don't have active Cl- transporters. As a result, the concentration gradient for Cl- is not 'set' like it is for Na+ and K+. There are, however, a limited number of Cl- leak channels in the cell membrane. As a result, Eci generally matches resting membrane potential - around - 70mV. Considering this, answer the following questions. If Cl- can cross the cell membrane, is not being actively transported, and membrane potential is -70mV, will there be a concentration gradient for Cl-?For which cation are there the largest number of leakage channels in the plasma membrane?Why do only a small number of sodium ions need to flow through the Na+ channel to change the membrane potential significantly?
- Similarly, what will be the effect on membrane potential if Cl- ions move into a cell?the maximal rate of solute movement during diffusion is greater than during mediated transport true or false?Ions like K+ cannot diffuse directly across the membrane. They need open ion channels to cross the membrane. Explain why.
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