Describe the mechanism through which a potassium channel can selectively move K* ions across a membrane while preventing the movement of smaller Na* ions.

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**Mechanism of Selective Ion Movement in Potassium Channels**

**Question:**  
Describe the mechanism through which a potassium channel can selectively move K⁺ ions across a membrane while preventing the movement of smaller Na⁺ ions.

**Answer:**  
Potassium channels achieve ion selectivity through a finely tuned structure-function relationship in their pore architecture. The selectivity filter of the potassium channel is composed of five amino acid residues forming a narrow passage specifically designed to accommodate dehydrated K⁺ ions. These residues coordinate with the K⁺ ions using backbone carbonyl oxygens, which mimic the hydration shell that K⁺ typically has in solution.

Despite the smaller diameter of Na⁺ ions, which might imply easier passage, Na⁺ ions do not pass through because the channel's architecture is optimized for the larger K⁺ ions. The energy required to strip water molecules from Na⁺ and rehydrate it in the channel is not favorably compensated by interactions with the carbonyl oxygens, prohibiting its passage. The precise geometry and chemical interactions at the selectivity filter provide the efficacy and specificity that enable the selective permeation of K⁺ over Na⁺, demonstrating the sophisticated nature of ion channels in cellular physiology.
Transcribed Image Text:**Mechanism of Selective Ion Movement in Potassium Channels** **Question:** Describe the mechanism through which a potassium channel can selectively move K⁺ ions across a membrane while preventing the movement of smaller Na⁺ ions. **Answer:** Potassium channels achieve ion selectivity through a finely tuned structure-function relationship in their pore architecture. The selectivity filter of the potassium channel is composed of five amino acid residues forming a narrow passage specifically designed to accommodate dehydrated K⁺ ions. These residues coordinate with the K⁺ ions using backbone carbonyl oxygens, which mimic the hydration shell that K⁺ typically has in solution. Despite the smaller diameter of Na⁺ ions, which might imply easier passage, Na⁺ ions do not pass through because the channel's architecture is optimized for the larger K⁺ ions. The energy required to strip water molecules from Na⁺ and rehydrate it in the channel is not favorably compensated by interactions with the carbonyl oxygens, prohibiting its passage. The precise geometry and chemical interactions at the selectivity filter provide the efficacy and specificity that enable the selective permeation of K⁺ over Na⁺, demonstrating the sophisticated nature of ion channels in cellular physiology.
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