The active drug substance given above contains a carboxylic acid group. Ionizable proton of carboxylic acid (circled in red taken), the pKa value is given as 3.5. This drug must be absorbed through the plasma membrane to pass. The speed of passage through the plasma membrane depends on the polarity of the molecule. Charged and polar molecules are slower than the membrane, neutral and hydrophobic molecules pass more rapidly. Your stomach Its pH is about 1.5 and the pH of the small intestine is about 6.0. whether this drug passes through the stomach or small intestine more into the blood. you wait Explain. In order to get full points, the ionic molecule in the stomach and intestines Compare them in terms of charge and polarity, indicating their state.
The active drug substance given above contains a carboxylic acid group. Ionizable proton of carboxylic acid (circled in red taken), the pKa value is given as 3.5. This drug must be absorbed through the plasma membrane to pass. The speed of passage through the plasma membrane depends on the polarity of the molecule. Charged and polar molecules are slower than the membrane, neutral and hydrophobic molecules pass more rapidly. Your stomach Its pH is about 1.5 and the pH of the small intestine is about 6.0. whether this drug passes through the stomach or small intestine more into the blood. you wait Explain. In order to get full points, the ionic molecule in the stomach and intestines Compare them in terms of charge and polarity, indicating their state.
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Question
The active drug substance given above contains a carboxylic acid group.
Ionizable proton of carboxylic acid (circled in red
taken), the pKa value is given as 3.5. This drug
must be absorbed through the plasma membrane to pass.
The speed of passage through the plasma membrane depends on the polarity of the molecule.
Charged and polar molecules are slower than the membrane, neutral and
hydrophobic molecules pass more rapidly. Your stomach
Its pH is about 1.5 and the pH of the small intestine is about 6.0.
whether this drug passes through the stomach or small intestine more into the blood.
you wait Explain. In order to get full points, the ionic molecule in the stomach and intestines
Compare them in terms of charge and polarity, indicating their state.
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