Answered: The active drug substance given above…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Question

The active drug substance given above contains a carboxylic acid group. Ionizable proton of carboxylic acid (circled in red taken), the pKa value is given as 3.5. This drug must be absorbed through the plasma membrane to pass. The speed of passage through the plasma membrane depends on the polarity of the molecule. Charged and polar molecules are slower than the membrane, neutral and hydrophobic molecules pass more rapidly. Your stomach Its pH is about 1.5 and the pH of the small intestine is about 6.0. whether this drug passes through the stomach or small intestine more into the blood. you wait Explain. In order to get full points, the ionic molecule in the stomach and intestines Compare them in terms of charge and polarity, indicating their state.

Definition Definition Class of organic compounds that contain a carboxyl group ( - COOH ) and has a general formula R - COOH or R - CO 2 H , where R refers to the alkyl, alkenyl, aryl, or other groups. They can undergo different chemical reactions, such as acid-base reactions, esterification, and oxidation. These are essential components of living organisms, playing important roles in metabolic processes, signaling, and as pharmaceuticals.

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