Consider the structure of following peptide from human brain. Identify part of the structure which is common in all the compounds 1-5. HO NH₂ OH This structural motif is essential for all these compounds to make binding interaction with the target protein and demonstrate pharmacological action. Use this information to justify why compounds 1 and 4 are active form of the drugs and compounds 2, 3 and 5 are prodrugs (an inactive version of the drug that must be activated in the body).
Consider the structure of following peptide from human brain. Identify part of the structure which is common in all the compounds 1-5. HO NH₂ OH This structural motif is essential for all these compounds to make binding interaction with the target protein and demonstrate pharmacological action. Use this information to justify why compounds 1 and 4 are active form of the drugs and compounds 2, 3 and 5 are prodrugs (an inactive version of the drug that must be activated in the body).
Biochemistry
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ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
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Transcribed Image Text:1.
20
2.
3.
4.
5.
#
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A new database release (version 2022 2) of the IUPHAR/BPS Guide to
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Primary drug Target
Themed includes
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for SARS-CoV-
2/COVID-19
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u-receptor
no-info
M-receptor
no-info
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the any proper
av 1800 pharmacool Lagets
Open Acces
biddo
pub
U
61JCA
How does the structure of these drugs affect its action on the primary drug target?
1901 100 b
Full agonist
Full agonist
no-info
Agonist
no-info
Transcribed Image Text:1.
20
2.
3.
4.
5.
#
Home
GtoPdb home page tour
Quick links
Targets
IUPHAR/BPS Guide to PHARMACOLOGY
An expert-curated resource of pharmacological targets and the substances that act on them
About - Targets
Advanced search
G protein-coupled receptors
lan channels
Nuclear hormone receptors
Kingses
Catalytic receptors
Transporters
Enzymes
Other protein targets
Ligands
Approved drugs
Synthetic organics
Metabolites
Natural products
Endogenous peptides
Compound
Other peptides
Inorganics
Antibodies
Labelled ligands
Resources
Help documentation
FAQ
Tutorial
Download data & reports
REST web services
FORS
Morphine
morphine
Codeinet
Oxycodone
Hydromorphone
Heroin
Ligands
WCP 2023
Diseases
WCP2023
2-7 JULY 2023
GLASGOW I SCOTLAND
AND CLINICAL PHARMACOLOIN
Resources -
Advanced Search: Targets | Target Pharmacology | Ligands | Chemical Structure
Current Release Version 2022 2 (9th June 2022) Read our release notes blog
Coronavirus (Covid-19) - view our information page
Pharmacology of COVID-19
BJP
نیاز
pharmacotherapeutic research and
development, which made the cover
of the issue.
Latest News and Hot Topics in Pharmacology
Database Release 2022.2
A new database release (version 2022 2) of the IUPHAR/BPS Guide to
Pharmacology was made on 9th June 2022. This blog post gives details of the
key content updates and website changes. CtoPcb now contains: 3,002 human
targets, 1,611 of which.
Read more >
3 months ago
Immuno Portal
Prof. Jamie Davies-RSE Fellow
Congratulations to Professor Jamie Davies, Professor of Experimental Anatomy,
University of Edinburgh, who has been elected to a Fellowship by The Royal
Primary drug Target
Themed includes
IUPHAR Review 29:
A rational roadmap
for SARS-CoV-
2/COVID-19
M- receptor
u-receptor
no-info
M-receptor
no-info
BAES
Malaria Portal
Search GtoPdb
Immunopharmacology
Action
IUPHAR Guide to
IMMUNOPHARMACOLOGY
An immunological access-
point to GtoPub data
Malaria Pharmacology
d
IUPHAR/MMV Guide to
MALARIA PHARMACOLOGY
Optimised access for the
malaria research community
The Concise Guide to
PHARMACOLOGY 2021/22
BJP
The Concise Guide to
PHARMACOLOGY 2021/22
dubla at
Consectet
the any proper
av 1800 pharmacool Lagets
Open Acces
biddo
pub
U
61JCA
How does the structure of these drugs affect its action on the primary drug target?
1901 100 b
Full agonist
Full agonist
no-info
Agonist
no-info
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