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Table 9.2 shows that Go’ for the aldolase reaction is large, and positive, yet the reaction proceeds in the forward direction. Using the metabolite concentrations in table 9.3, calculate the actual G in the cell for the reaction to show that it is consistent with the value reported in table 9.2. Explain in words the strategy the cell uses to keep glycolysis moving in the forward direction (1-2 sentences).

Table 9.2 shows that Go’ for the aldolase reaction is large, and positive, yet the reaction proceeds in the forward direction. Using the metabolite concentrations in table 9.3, calculate the actual G in the cell for the reaction to show that it is consistent with the value reported in table 9.2. Explain in words the strategy the cell uses to keep glycolysis moving in the forward direction (1-2 sentences).

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
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Table 9.2 shows that Go’ for the aldolase reaction is large, and positive, yet the reaction
proceeds in the forward direction. Using the metabolite concentrations in table 9.3, calculate the actual
G in the cell for the reaction to show that it is consistent with the value reported in table 9.2. Explain in
words the strategy the cell uses to keep glycolysis moving in the forward direction (1-2 sentences).

Table 9.3 Metabolite Glucose Glucose-6-phosphate 0.083 Fructose-6-phosphate Fructose-1,6-bisphosphate Dihydroxyacetone phosphate Glyceraldehyde-3-phosphate 1,3-Bisphosphoglycerate 3-Phosphoglycerate 2-Phosphoglycerate Phosphoenolpyruvate Pyruvate ATP ADP Pi Concentration (mm) 5 0.083 0.014 0.031 0.138 0.019 0.004 0.118 0.030 0.023 0.051 1.85 0.138 1
Transcribed Image Text:Table 9.3 Metabolite Glucose Glucose-6-phosphate 0.083 Fructose-6-phosphate Fructose-1,6-bisphosphate Dihydroxyacetone phosphate Glyceraldehyde-3-phosphate 1,3-Bisphosphoglycerate 3-Phosphoglycerate 2-Phosphoglycerate Phosphoenolpyruvate Pyruvate ATP ADP Pi Concentration (mm) 5 0.083 0.014 0.031 0.138 0.019 0.004 0.118 0.030 0.023 0.051 1.85 0.138 1
Reaction Table 9.2 1. Glucose + ATP → Glucose-6-phosphate + ADP 2. Glucose-6-phosphate → Fructose-6- phosphate 3. Fructose-6-phosphate + ATP → Fructose-1,6- bisphosphate + ADP 4. Fructose-1,6- bisphosphate Dihydroxyacetone phosphate + Glyceraldehyde-3-phosphate 5. Dihydroxyacetone phosphate Glyceraldehyde-3-phosphate 6. Glyceraldehyde-3- phosphate + Pi + NAD › 1,3- Bisphosphoglycerate + NADH + H* 8. 3-Phosphoglycerate → 2- Phosphoglycerate 9. 2-Phosphoglycerate Phosphoenolpyruvate + H20 Enzyme 10. Phosphoenolpyruvate + ADP → Pyruvate + ATP Hexokinase Phosphoglucoisomerase Phosphofructokinase-1 Aldolase Glyceraldehyde-3- phosphate dehydrogenase 7. 1,3- Bisphosphoglycerate + ADP → 3- | Phosphoglycerate kinase -18.8 Phosphoglycerate + ATP Phosphoglycerate mutase AGO (kJ/mol) -16.7 Triose phosphate isomerase +7.5 Enolase +1.7 Pyruvate kinase -14.2 +23.8 +6.3 +4.6 +1.7 -31.4
Transcribed Image Text:Reaction Table 9.2 1. Glucose + ATP → Glucose-6-phosphate + ADP 2. Glucose-6-phosphate → Fructose-6- phosphate 3. Fructose-6-phosphate + ATP → Fructose-1,6- bisphosphate + ADP 4. Fructose-1,6- bisphosphate Dihydroxyacetone phosphate + Glyceraldehyde-3-phosphate 5. Dihydroxyacetone phosphate Glyceraldehyde-3-phosphate 6. Glyceraldehyde-3- phosphate + Pi + NAD › 1,3- Bisphosphoglycerate + NADH + H* 8. 3-Phosphoglycerate → 2- Phosphoglycerate 9. 2-Phosphoglycerate Phosphoenolpyruvate + H20 Enzyme 10. Phosphoenolpyruvate + ADP → Pyruvate + ATP Hexokinase Phosphoglucoisomerase Phosphofructokinase-1 Aldolase Glyceraldehyde-3- phosphate dehydrogenase 7. 1,3- Bisphosphoglycerate + ADP → 3- | Phosphoglycerate kinase -18.8 Phosphoglycerate + ATP Phosphoglycerate mutase AGO (kJ/mol) -16.7 Triose phosphate isomerase +7.5 Enolase +1.7 Pyruvate kinase -14.2 +23.8 +6.3 +4.6 +1.7 -31.4
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