The free energy change of each step of glycolysis is given in the table below. ∆G°’ is the free energy under standard conditions (25°C, 1M each reactant, pH 7), while ∆G is the free energy change at presumed physiological conditions. Why must no step have a positive ∆G under physiological conditions?

Q: Reactions and Thermodynamics of Glycolysis

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Q: Why does this step in particular proceed spontaneously under typical cellular conditions?

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