Some individuals in a canine population is susceptible to disease X, which strikes the adults. The susceptibility is later found to be determined by a single locus, with the R allele dominant over the r allele, such that the rr individuals are susceptible to the disease and the others immune. A population genetic survey showed that 1% of the newborns carry the rr genotype. Also, an independent estimation showed that mutation rate converting R to r is 5 x 103 per generation. You suspected that ther allele frequency is maintained by mutation- selection balance (MSB). If your hypothesis of MSB is true, then what is the survival rate for the rr adults? (Note: the equilibrium allele frequency ĝ is calculated as ĝ = 1/ where u is the mutation rate and s is the selection coefficient.) O 5% O 50% O 95% 99% None of the above

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
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Chapter1: The Human Body: An Orientation
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Some individuals in a canine population is susceptible to disease X, which strikes the
adults. The susceptibility is later found to be determined by a single locus, with the R allele
dominant over the r allele, such that the rr individuals are susceptible to the disease and the
others immune. A population genetic survey showed that 1% of the newborns carry the rr
genotype. Also, an independent estimation showed that mutation rate converting R to r is 5
× 10-3 per generation. You suspected that the r allele frequency is maintained by mutation-
selection balance (MSB). If your hypothesis of MSB is true, then what is the survival rate
for the rr adults? (Note: the equilibrium allele frequency ĝ is calculated as ĝ
where
%3D
u is the mutation rate and s is the selection coefficient.)
5%
50%
95%
99%
None of the above
Transcribed Image Text:Some individuals in a canine population is susceptible to disease X, which strikes the adults. The susceptibility is later found to be determined by a single locus, with the R allele dominant over the r allele, such that the rr individuals are susceptible to the disease and the others immune. A population genetic survey showed that 1% of the newborns carry the rr genotype. Also, an independent estimation showed that mutation rate converting R to r is 5 × 10-3 per generation. You suspected that the r allele frequency is maintained by mutation- selection balance (MSB). If your hypothesis of MSB is true, then what is the survival rate for the rr adults? (Note: the equilibrium allele frequency ĝ is calculated as ĝ where %3D u is the mutation rate and s is the selection coefficient.) 5% 50% 95% 99% None of the above
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