Two families are genotyped at a marker with alleles M and m. Genotypes at a disease gene, with alleles D and d, are inferred from the larger pedigrees (not shown). The genotype of each individual is displayed below. The phase of each individual is indicated with a horizontal bar. One chromosome has the combination of alleles above the bar and the other chromosome has the combination of alleles below the bar. Use this information to complete the following tasks: A. Labeling the children as 1, 2, and 3 moving from left to right along the chart, indicate whether each child's genotype arose from a recombinant or non-recombinant gamete from their heterozygous parent. B. Write down the formula for the combined odds ratio across the two families for linkage vs. no linkage as a function of the recombination frequency (r). You do not need to simplify your expression. Family #1 MD m d md m Family #2 MD MD n D Md md MD
Two families are genotyped at a marker with alleles M and m. Genotypes at a disease gene, with alleles D and d, are inferred from the larger pedigrees (not shown). The genotype of each individual is displayed below. The phase of each individual is indicated with a horizontal bar. One chromosome has the combination of alleles above the bar and the other chromosome has the combination of alleles below the bar. Use this information to complete the following tasks: A. Labeling the children as 1, 2, and 3 moving from left to right along the chart, indicate whether each child's genotype arose from a recombinant or non-recombinant gamete from their heterozygous parent. B. Write down the formula for the combined odds ratio across the two families for linkage vs. no linkage as a function of the recombination frequency (r). You do not need to simplify your expression. Family #1 MD m d md m Family #2 MD MD n D Md md MD
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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