Select all of the following that accurately apply to acyl-CoA synthetase and the transport of acyl-CoA through the carnitine transport system in the liver: 0 0 00 00 Acyl-CoA is formed when CoA serves as a nucleophile for attack of the fatty acyl-adenylate intermediate Fatty acid carbon skeletons are simultaneously used in the liver for beta oxidation and glucose biosynthesis The carnitine transport system is inhibited in the presence of high amounts of malonyl CoA The carrier protein carnitine replaces CoA in the transport of fatty acyl groups across the inner- mitochondrial membrane and allows acyl-CoA reformation in the matrix Increased need for beta oxidation allows for decreased transport of fatty acids via the carnitine transport system The formation of acyl-CoA by acyl-CoA synthetase involves the use of 2 equivalents of ATP - (1) an ATP used for activation of fatty acyl-adenylate and (2) an equivalent of ATP in the form of pyrophosphate hydrolysis

Biochemistry
6th Edition
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Reginald H. Garrett, Charles M. Grisham
Chapter19: The Tricarboxylic Acid Cycle
Section: Chapter Questions
Problem 22P: Study Figure 19.18 and decide which of the following statements is false. Pyruvate dehydrogenase is...
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Select all of the following that accurately apply to acyl-CoA synthetase and the transport of acyl-CoA through the carnitine transport system in
the liver:
00
☐☐☐☐
Acyl-CoA is formed when CoA serves as a nucleophile for attack of the fatty acyl-adenylate intermediate
Fatty acid carbon skeletons are simultaneously used in the liver for beta oxidation and glucose
biosynthesis
The carnitine transport system is inhibited in the presence of high amounts of malonyl CoA
The carrier protein carnitine replaces CoA in the transport of fatty acyl groups across the inner-
mitochondrial membrane and allows acyl-CoA reformation in the matrix
Increased need for beta oxidation allows for decreased transport of fatty acids via the carnitine transport
system
The formation of acyl-CoA by acyl-CoA synthetase involves the use of 2 equivalents of ATP - (1) an ATP
used for activation of fatty acyl-adenylate and (2) an equivalent of ATP in the form of pyrophosphate
hydrolysis
Transcribed Image Text:Select all of the following that accurately apply to acyl-CoA synthetase and the transport of acyl-CoA through the carnitine transport system in the liver: 00 ☐☐☐☐ Acyl-CoA is formed when CoA serves as a nucleophile for attack of the fatty acyl-adenylate intermediate Fatty acid carbon skeletons are simultaneously used in the liver for beta oxidation and glucose biosynthesis The carnitine transport system is inhibited in the presence of high amounts of malonyl CoA The carrier protein carnitine replaces CoA in the transport of fatty acyl groups across the inner- mitochondrial membrane and allows acyl-CoA reformation in the matrix Increased need for beta oxidation allows for decreased transport of fatty acids via the carnitine transport system The formation of acyl-CoA by acyl-CoA synthetase involves the use of 2 equivalents of ATP - (1) an ATP used for activation of fatty acyl-adenylate and (2) an equivalent of ATP in the form of pyrophosphate hydrolysis
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