Select all of the following that accurately apply to acyl-CoA synthetase and the transport of acyl-CoA through the carnitine transport system in the liver: 0 0 00 00 Acyl-CoA is formed when CoA serves as a nucleophile for attack of the fatty acyl-adenylate intermediate Fatty acid carbon skeletons are simultaneously used in the liver for beta oxidation and glucose biosynthesis The carnitine transport system is inhibited in the presence of high amounts of malonyl CoA The carrier protein carnitine replaces CoA in the transport of fatty acyl groups across the inner- mitochondrial membrane and allows acyl-CoA reformation in the matrix Increased need for beta oxidation allows for decreased transport of fatty acids via the carnitine transport system The formation of acyl-CoA by acyl-CoA synthetase involves the use of 2 equivalents of ATP - (1) an ATP used for activation of fatty acyl-adenylate and (2) an equivalent of ATP in the form of pyrophosphate hydrolysis

Select all of the following that accurately apply to acyl-CoA synthetase and the transport of acyl-CoA through the carnitine transport system in the liver: 0 0 00 00 Acyl-CoA is formed when CoA serves as a nucleophile for attack of the fatty acyl-adenylate intermediate Fatty acid carbon skeletons are simultaneously used in the liver for beta oxidation and glucose biosynthesis The carnitine transport system is inhibited in the presence of high amounts of malonyl CoA The carrier protein carnitine replaces CoA in the transport of fatty acyl groups across the inner- mitochondrial membrane and allows acyl-CoA reformation in the matrix Increased need for beta oxidation allows for decreased transport of fatty acids via the carnitine transport system The formation of acyl-CoA by acyl-CoA synthetase involves the use of 2 equivalents of ATP - (1) an ATP used for activation of fatty acyl-adenylate and (2) an equivalent of ATP in the form of pyrophosphate hydrolysis

Biochemistry

6th Edition

ISBN:9781305577206

Author:Reginald H. Garrett, Charles M. Grisham

Publisher:Reginald H. Garrett, Charles M. Grisham

Chapter19: The Tricarboxylic Acid Cycle

Section: Chapter Questions

Problem 22P: Study Figure 19.18 and decide which of the following statements is false. Pyruvate dehydrogenase is...

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Which of the following most accurately describes the impact acetyl-CoA has in the cytosol of the liver cell? Acetyl CoA serves as an allosteric inhibitor of PFK Acetyl CoA serves as an allosteric inhibitor of pyruvate kinase Acetyl CoA serves as an allosteric activator of PFK Acetyl CoA serves as an allosteric activator of pyruvate kinase Acetyl CoA serves as an allosteric activator of fructose-2,6-bisphosphatase Acetyl CoA serves as an allosteric activator of PFK-2
Which of the following statements is falseconcerning acetyl CoA carboxylase (ACC)? ACC is more active when protomers condense to form polymers Palmitoyl CoA serves as a feedback inhibitor The source of carbons for ACC comes from the carbon skeletons of malate that is exported from the matrix of the mitochondria in the form of malate Binding of glucagon triggers cAMP production, which leads to inhibition of ACC
Part A Identify each of the following metabolic pathways. Drag the appropriate labels to their respective targets. Reset Help the conversion of fatty acids to 2-carbon units of acetyl CoA ketogenesis the conversion of an amino acid to an a-keto transamination acid the combination of 2-carbon units of acetyl COA to form fatty acids oxidative deamination the removal of an amino group as NH4+ from B oxidation glutamate to yield a-ketoglutarate lipogenesis the production of ketone bodies
Which reaction below corresponds with substrate level phosphorylation? Fructose-1,6-bisphosphoglycerate >>>> G3P Pyruvate >>>> Acetyl-CoA Glucose >>>> Glucose-6-phosphate 1,3-bisphosphoglycerate >>>> 3-phosphoglycerate >>>> pyruvate Acetyl + Oxaloacetate >>>> Citrate
Fatty acids are activated for breakdown through the action of acyl-CoA synthestase. Which of the following statements regarding acyl-CoA synthetase is not true? ● It catalyzes the addition of CoA to the fatty acid One of the products of the reaction is ADP. O The free energy change for the reaction catalyzed by this reaction is close to 0 kJ/mol, but the subsequent hydrolysis of pyrophosphate drives the reaction forward. O The reaction results in the formation of a thioester bond.
All of the following are accurate contrasts for beta oxidation vs fatty acid synthesis except which of the following statements? Group of answer choices The hydroxylacyl group differs in stereochemistry between beta oxidation and biosynthesis CoA is the acyl carrier group in beta oxidation, acyl carrier protein is the carrier in biosynthesis The carbon unit resulting from beta oxidation is acetyl-CoA, the carbon unit for biosynthesis is malonyl-CoA FAD is an electron acceptor in beta oxidation, NADP+ is the electron acceptor in biosynthesis
If glucose labeled at carbon-3 is fed into the citrate-malate-pyruvate shuttle, which carbons of the pyruvate, acetyl-CoA, and citrate would you expect to be labeled? Would you expect the label to be incorporated into palmitic acid? Pyruvate will have a label at carbon Acetyl-CoA will have Citrate immediately exported to the cytosol will have a label at The label in palmitic acid.
B-oxidation of a 15:0 fatty acid will result in the production of O 7 acetyl CoA, 7 FADH2, and 7 NADH O 7 acetyl CoA, 1 propionyl CoA, 8 FADH2, and 8 NADH 6 acetyl CoA, 1 propionyl CoA, 7 FADH2, and 7 NADH 6 acetyl CoA, 1 propionyl CoA, 6 FADH2, and 6 NADH
Which of the following statements is TRUE about fatty acid biosynthesis? Citrate carries malonyl CoA to the cytosol. O Acetyl ACP is the donor of the acetyl group. O NADPH is used as the reducing equivalent in the process. O The product detaches from the fatty acid synthase complex when the chain length is usually 18 carbons.
Propose a mechanism for the following reaction:
Which of the following statements is TRUE about fatty acid biosynthesis? Group of answer choices: NADH is used as the reducing equivalent in the process. Malonyl ACP is the donor of the acetyl group. The product detaches from the fatty acid synthase complex when the chain length is usually 18 carbons. Oxaloacetate carries acetyl CoA to the cytosol.
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