Researchers who study those rods cells have performed a series of experiments to better understand this phototransduction pathway and the role of this PDE protein in patients that suffer from night blindness. In one experiment, researchers have measured the cytosolic concentration of cGMP (cyclic- GMP) under different light intensities (exposure = 10 min) in both the presence and the absence of the PDE6i inhibitor. The results are as follow: the cytosolic concentration of cGMP (cyclic-GMP) decreases as light intensity increases, but only in the absence of the PDE6i inhibitor (see figure below). Without PDE6i cGMP concentration (A.U) 25 20 15- 10- 0 0 0.1 0.2 0.3 Light intensity (A.U) -25 C. It is a messenger RNA D. It is a hormone E. It is a phospholipid -20 -10 0.4 5 0 GMP concentration (A.U) cGMP concentration (A.U) 25 20 15- 10- 0 0.1 With PDE6i 0.2 0.3 Light intensity (A.U) 25 0.4 20 -0 GMP concentration (A.U) 10. What is the likely function of the cytosolic cGMP in this phototransduction pathway? A. It is a competitive inhibitor of PDE B. It is a second messenger
Researchers who study those rods cells have performed a series of experiments to better understand this phototransduction pathway and the role of this PDE protein in patients that suffer from night blindness. In one experiment, researchers have measured the cytosolic concentration of cGMP (cyclic- GMP) under different light intensities (exposure = 10 min) in both the presence and the absence of the PDE6i inhibitor. The results are as follow: the cytosolic concentration of cGMP (cyclic-GMP) decreases as light intensity increases, but only in the absence of the PDE6i inhibitor (see figure below). Without PDE6i cGMP concentration (A.U) 25 20 15- 10- 0 0 0.1 0.2 0.3 Light intensity (A.U) -25 C. It is a messenger RNA D. It is a hormone E. It is a phospholipid -20 -10 0.4 5 0 GMP concentration (A.U) cGMP concentration (A.U) 25 20 15- 10- 0 0.1 With PDE6i 0.2 0.3 Light intensity (A.U) 25 0.4 20 -0 GMP concentration (A.U) 10. What is the likely function of the cytosolic cGMP in this phototransduction pathway? A. It is a competitive inhibitor of PDE B. It is a second messenger
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Transcribed Image Text:Researchers who study those rods cells have performed a series of experiments to better understand
this phototransduction pathway and the role of this PDE protein in patients that suffer from night
blindness. In one experiment, researchers have measured the cytosolic concentration of cGMP (cyclic-
GMP) under different light intensities (exposure = 10 min) in both the presence and the absence of the
PDE6i inhibitor.
The results are as follow: the cytosolic concentration of cGMP (cyclic-GMP) decreases as light intensity
increases, but only in the absence of the PDE6i inhibitor (see figure below).
Without PDE6i
cGMP concentration (A.U)
25
20
15-
0-
0
0.1
0.2
0.3
Light intensity (A.U)
25
0.4
20
15
- 10
5
0
GMP concentration (A.U)
cGMP concentration (A.U)
25
20
15-
o
0-
0
0.1
With PDE6i
0.2
0.3
Light intensity (A.U)
0.4
25
20
0
GMP concentration (A.U)
10. What is the likely function of the cytosolic cGMP in this phototransduction pathway?
A. It is a competitive inhibitor of PDE
B. It is a second messenger
C. It is a messenger RNA
D. It is a hormone
E. It is a phospholipid
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